Gholamin and colleagues treated malignant pediatric brain tumor models with a humanized anti-CD47 antibody (Hu59-G4). In primary and metastatic high-risk medulloblastoma, Hu5F9-G4 inhibited growth in vivo , including CD15-positive putative medulloblastoma stem cells. Because children with g ... more
Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrrolobenzodiazepine dimer (PBD) or tubulysin p ... more
In this article [(Cancer Res 2016;76:5756–67)], which appeared in the October 1, 2016, issue of Cancer Research (), there are errors in Figs. 2A and 6E. The authors used one trimmed image/blot to fit the size of the others. In these two panels, they accidentally kept the “ruler image/ more
In a phase Ia clinical trial, immune cells called Tregs, which can inhibit anticancer immune responses, were efficiently eliminated from the blood of patients with lung or esophageal cancer by treatment with the investigational therapeutic antibody KW-0761.
Author(s): Ryuzo Ueda, MD, PhD, p ... more