No abstract is available for this article. more
To use all functions of this page, please activate cookies in your browser.
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
Glycoprotein hormone receptors contain large extracellular domains encoded by multiple exons that can be alternatively spliced. Using human ovarian surface epithelium, we cloned two new splice variants of the human follicle‐stimulating hormone receptor (FSH‐R) gene, hFSH‐R2 and hFSH‐R3. The hFSH‐R2 splice variant differed from the full‐length FSH‐R mRNA by the deletion of exon 10 and inclusion of two small exons after exon 9 whereas the hFSH‐R3 splice variant retained only exons 1–6 of the full‐length transcript. Both variants were expressed at low levels, but were detected in cells from follicular fluid derived from 30 different subjects. Transfection of these two variants individually into KGN cells, an ovarian cancer cell line that expresses wild‐type FSH‐R, reduced FSH‐mediated phosphorylation of ERK1/2, Akt, and p38/MAPK. Furthermore, in vitro co‐expression of either hFSH‐R2 or hFSH‐R3 and full‐length FSH‐R in HEK293T cells reduced signal transduction through full‐length FSH‐R. Further studies are needed to fully elucidate the functions of these receptor isoforms. Mol. Reprod. Dev. 2013. © 2013 Wiley Periodicals, Inc.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... more
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... more
Smart skin that can respond to external stimuli could have important applications in medicine and robotics. Using only items found in a typical household, researchers have created multi-sensor artificial skin that's capable of sensing pressure, temperature, humidity, proximity, pH, and air ... more
Some doctors may recommend that patients with the flu take acetaminophen, or paracetemol, to relieve their symptoms; however, a new randomized clinical trial found no benefits to the over-the-counter medication in terms of fighting the influenza virus or reducing patients' temperature or ot ... more
A new study that investigated the potential of certain psychological traits for predisposing heterosexuals to have negative attitudes towards homosexual people found that psychoticism - which is present in severe psychopathological conditions but may also contribute to less severe states of ... more