My watch list
my.bionity.com  
Login  

Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases [Neuroscience]

In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots of this phenomenon, we created a knock-in mouse model carrying the mutation associated with one of these diseases [Creutzfeldt–Jakob disease...

Authors:   Walker S. Jackson; Andrew W. Borkowski; Nicki E. Watson; Oliver D. King; Henryk Faas; Alan Jasanoff; Susan Lindquist
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   110
edition:   36
Year:   2013
Pages:   14759
DOI:   10.1073/pnas.1312006110
Publication date:   03-Sep-2013
Facts, background information, dossiers
More about Proceedings of the National Academy of Sciences
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE