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Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes [Medical Sciences]

The clinical management of nonhealing ulcers requires advanced materials that improve wound-closure rates without relying on the release of drugs or other growth factors that could potentially lead to concerns regarding systemic deleterious side effects. We report the synthesis, characterization, and performance of a biodegradable antioxidant shape-conforming regenerative dressing that exploits α3β1 and α6β1 integrin-binding interactions to promote dermal tissue regeneration. A laminin-derived peptide grafted onto a thermoresponsive citrate-based macromolecular scaffold facilitates the adhesion and spreading of skin cells throughout the hydrogel and also significantly increases cell proliferation and migration in an integrin-dependent manner. We use a splinted excisional wound diabetic mouse model to demonstrate that application of this thermoresponsive regenerative dressing significantly accelerates wound closure in vivo.

Authors:   Yunxiao Zhu; Zdravka Cankova; Marta Iwanaszko; Sheridan Lichtor; Milan Mrksich; Guillermo A. Ameer
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   26
Year:   2018
Pages:   6816
DOI:   10.1073/pnas.1804262115
Publication date:   26-Jun-2018
Facts, background information, dossiers
  • skin cells
  • side effects
  • lead
More about Proceedings of the National Academy of Sciences
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