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Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells [Immunology and Inflammation]

Production of high-affinity antibody responses after infection or vaccination requires precise control of germinal center B cells by follicular helper T cells and follicular regulatory T cells. Although the Bcl6 transcription factor plays a central role in follicular T cell differentiation, the molecular basis of Bcl6 control has been clouded in uncertainty. Here we report that Bcl6-dependent control reflects the formation of a macromolecular complex between Bcl6 and the Mi-2β-nucleosome remodeling deacetylase complex (Mi-2β-NuRD). The repressive activity of this intranuclear complex potentiates the follicular T cell phenotype and inhibits alternative T cell fates. Identification of this intracellular complex may facilitate new targeted approaches to the treatment of autoimmune disorders.

Authors:   Erxia Shen; Qin Wang; Hardis Rabe; Wenquan Liu; Harvey Cantor; Jianmei W. Leavenworth
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   26
Year:   2018
Pages:   6780
DOI:   10.1073/pnas.1805239115
Publication date:   26-Jun-2018
Facts, background information, dossiers
  • Formation
  • B cells
More about Proceedings of the National Academy of Sciences
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