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Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein [Microbiology]

The outer membrane of Gram-negative bacteria is a highly impermeable barrier to a range of toxic chemicals and is responsible for the resistance of these bacteria to important classes of antibiotics. In this work, we show that plant pathogenic Pectobacterium spp. acquire iron from the small, stable, and abundant iron-containing plant protein ferredoxin by transporting ferredoxin across the outer membrane for intracellular processing by a highly specific protease, which induces iron release. The presence of homologous uptake and processing proteins in a range of important animal and plant pathogens suggests an exploitable route through which large molecules can penetrate the outer membrane of Gram-negative bacteria.

Authors:   Khedidja Mosbahi; Marta Wojnowska; Amaya Albalat; Daniel Walker
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   26
Year:   2018
Pages:   6840
DOI:   10.1073/pnas.1800672115
Publication date:   26-Jun-2018
Facts, background information, dossiers
  • ferredoxin
  • Cleavage
  • chemicals
More about Proceedings of the National Academy of Sciences
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