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An archaeal primase functions as a nanoscale caliper to define primer length [Biochemistry]

The first phosphodiester linkage made during DNA replication is in the context of a short RNA primer synthesized by the dedicated RNA polymerase, primase. Primase, after synthesizing a defined short oligoribonucleotide, then transfers this primer to a DNA polymerase for extension. The mechanisms by which primer length is constrained remain elusive. Here, we dissect the basis of “counting” by an archaeal primase and propose a caliper-like mechanism to account for length determination.

Authors:   Jiangyu Yan; Sandro Holzer; Luca Pellegrini; Stephen D. Bell
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   26
Year:   2018
Pages:   6697
DOI:   10.1073/pnas.1806351115
Publication date:   26-Jun-2018
Facts, background information, dossiers
  • Determination
  • biochemistry
More about Proceedings of the National Academy of Sciences
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