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Tyrosinase inhibition by a rare neolignan: inhibition kinetics and mechanistic insights through in vitro and in silico studies

Publication date:

Available online 20 June 2018

Source:Computational Biology and Chemistry

Author(s): Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel

Neolignans are a large group of polyphenols found in plants and exhibit a wide range of bioactivities including cytotoxicity, apoptosis inducer, antimalarial and antifungal effects, acetylcholinesterase, tyrosinase, and α-glucosidase inhibition. In this study we tested acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), tyrosinase, and α-glucosidase inhibitory effects of a rare neolignan, (-)-4-O-methyldehydrodiconiferyl alcohol 9'-O-β-glucopyranoside (1) in search for its new pharmaceutical effects. This compound exhibited good tyrosinase inhibition with an IC50 value of 44.62 ± 3.99 µg/mL. Enzyme kinetics and molecular modelling studies were performed to provide insights into its tyrosinase inhibition mechanism.
Graphical abstract

Authors:   Author(s): Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel
Journal:   Computational Biology and Chemistry
Year:   2018
Publication date:   24-Jun-2018
Facts, background information, dossiers
  • tyrosinase
  • acetylcholinesterase
  • polyphenols
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