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Viruses, Vol. 10, Pages 341: Role of T-Helper 9 Cells in Chronic Hepatitis C-Infected Patients

Viruses, Vol. 10, Pages 341: Role of T-Helper 9 Cells in Chronic Hepatitis C-Infected Patients

Viruses doi: 10.3390/v10070341

Authors: Mohamed E. Ali Omnia El-Badawy Noha A. Afifi Abeer Sharaf Eldin Elham Ahmed Hassan Hamada M. Halby Mohamed Ahmed El-Mokhtar

Hepatitis C virus is a hepatotropic virus that is transmitted parenterally. Viral infections are usually associated with modulations of the immune cells, leading to enhanced viral survival and spreading, and accordingly, life-threatening complications. Recently, it has been proposed that a new subset of T-helper, named T-helper 9, is involved in the pathogenesis of different immunopathological conditions, such as allergies, tumors, and viral infections. Some studies reported a protective role, and others described a pathogenic potential for the T-helper 9 cells. Here, we present evidence that T-helper 9 cells are dynamically increased with increasing the pathogenic strategy for hepatitis C virus (HCV). Furthermore, viral clearance is associated with a decrease in T-helper 9. The increase in T-helper 9 was paralleled with an increase in its receptor expression. Taken together, our data suggest that T-helper 9 cells play an important role in the pathogenesis of HCV, and is directly associated with HCV-related complications.

Authors:   Ali, Mohamed E.; El-Badawy, Omnia ; Afifi, Noha A.; Eldin, Abeer Sharaf; Hassan, Elham Ahmed; Halby, Hamada M.; El-Mokhtar, Mohamed Ahmed
Journal:   Viruses
Volume:   10
edition:   7
Year:   2018
Pages:   341
DOI:   10.3390/v10070341
Publication date:   24-Jun-2018
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