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Electronic cigarette aerosols induce DNA damage and reduce DNA repair: Consistency across species [Biological Sciences]

We read with great interest the work of Lee et al. (1), in which the authors report that mice exposed to electronic cigarette aerosol have increased levels of DNA lesions and decreased DNA repair activity. This work sparked important discussion both in PNAS (2, 3) and science media (4). We do share some concerns previously raised, including the very high dose of electronic cigarette aerosol exposure and the lack of plasma nicotine measurements. Additionally, while we agree with the authors that the exposure to electronic cigarette aerosol led to an increase in O6-methyl-deoxuguanosine and γ-hydroxy-1, N2 -propano-deoxyguanosines adducts, we do not share their … [↵][1]1To whom correspondence should be addressed. Email: Lurdes-queimado{at} [1]: #xref-corresp-1-1

Authors:   Lurdes Queimado; Theodore Wagener; Vengatesh Ganapathy
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   24
Year:   2018
Pages:   E5437
DOI:   10.1073/pnas.1807411115
Publication date:   12-Jun-2018
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