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Transcriptional signature of the decidua in preeclampsia [Biological Sciences]

An emerging concept is that the genesis of preeclampsia is rooted in dysregulated decidualization (1). In PNAS, Garrido-Gomez et al. (2) demonstrate a distinct transcriptional signature in the endometrial stromal cells (ESCs) of preeclampsia patients compared with control cells during in vitro decidualization (before pregnancy) and in vivo decidualization (after pregnancy). This finding has important implications for the development of therapies focused on improving decidualization to prevent severe preeclampsia. Garrido-Gomez et al. (2) used the secretion of prolactin (PRL) and insulin-like growth factor binding protein 1 (IGFBP1) proteins as a marker of decidualization. We established an in vitro decidualization model in immortalized human ESC cells (ATCC Catalog No. CRL-4003) by treatment with cAMP and medroxyprogesterone acetate for 5 d. RNA-seq analysis revealed 1,359 differentially expressed genes, of which 584 genes were up-regulated and 775 genes were down-regulated upon in vitro decidualization [fold-change > 2 and false-discovery … [↵][1]1To whom correspondence should be addressed. Email: jilongliu{at}scau.edu.cn. [1]: #xref-corresp-1-1

Authors:   Ji-Long Liu; Wen-Qian Zhang; Ming-Yu Huang
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   24
Year:   2018
Pages:   E5434
DOI:   10.1073/pnas.1802234115
Publication date:   12-Jun-2018
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