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Fear memory is a highly stable and durable form of memory, even over vast (remote) time frames. Nevertheless, some elements of fear memory can be forgotten, resulting in generalization. The purpose of this study is to determine how cued fear memory generalizes over time and measure underlying patterns of cortico-amygdala synaptic plasticity. We established generalization gradients at recent (1-d) and remote (30-d) retention intervals following auditory cued fear conditioning in adult male C57BL/6 mice. Results revealed a flattening of the generalization gradient (increased generalization) that was dissociated from contextual fear generalization, indicating a specific influence of time on cued fear memory performance. This effect reversed after a brief exposure to the novel stimulus soon after learning. Measurements from cortico-amygdala imaging of the activity-regulated cytoskeletal Arc/arg 3.1 (Arc) protein using immunohistochemistry after cued fear memory retrieval revealed a stable pattern of Arc expression in the dorsolateral amygdala, but temporally dynamic expression in the cortex. Over time, increased fear memory generalization was associated with a reduction in Arc expression in the agranular insular and infralimbic cortices while discrimination learning was associated with increased Arc expression in the prelimbic cortex. These data identify the dorsolateral amygdala, medial prefrontal, and insular cortices as loci for synaptic plasticity underlying cued fear memory generalization over time.
| Authors: | Gabrielle A. Pollack; Jessica L. Bezek; Serena H. Lee; Miranda J. Scarlata; Leah T. Weingast; Hadley C. Bergstrom | |
| Journal: | Learning & Memory | |
| Volume: | 25 | |
| edition: | 7 | |
| Year: | 2018 | |
| Pages: | 298 | |
| DOI: | 10.1101/lm.047555.118 | |
| Publication date: | 01-Jul-2018 |
We tested the proposal that medial temporal lobe (MTL) structures support not just memory but also high-level object perception. In one task, participants decided whether a line drawing could represent an object in three-dimensional space and, in another task, they saw the components of an ... more
Properties of visual episodic memory following repeated encounters with objects [RESEARCH]
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Novel gene variants identified in male breast cancer
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Novel regulator inhibits toxic protein aggregates in Huntington's disease
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Mutation detection in human in vitro fertilized embryos using whole-genome sequencing
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