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Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis [Pharmacology]

Obesity and chronic inflammation are two well-recognized risk factors for the development of colorectal cancer (CRC). In PNAS, Wang et al. (1) use lipidomic profiling analysis to identify a significant mechanistic link between obesity and colonic inflammation via enhancing the proinflammatory enzyme soluble epoxide hydrolase (sEH). The aberrant metabolism of polyunsaturated fatty acids, and particularly arachidonic acid, is thought to be a key inflammatory mediator contributing to colorectal carcinogenesis. The role of cytochrome P450 epoxygenase in this metabolism, though, and the role of its epoxy fatty acid metabolites in obesity and CRC are not … [↵][1]1Email: g-yang{at}northwestern.edu. [1]: #xref-corresp-1-1

Authors:   Guang-Yu Yang
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   23
Year:   2018
Pages:   5827
DOI:   10.1073/pnas.1807520115
Publication date:   05-Jun-2018
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