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A neural pathway controlling motivation to exert effort [Neuroscience]

The lateral habenula, a brain region that has been implicated in depression, receives inputs from brain nuclei associated with basic emotions and drives. In this report, using fiber photometry and optogenetics on behaving rats, we show that one major lateral habenula output pathway controls the motivation to exert effort in both aversive and appetitive contexts. Overactivity of this pathway could contribute to the reduced motivation seen in human depression.

Authors:   Christophe D. Proulx; Sage Aronson; Djordje Milivojevic; Cris Molina; Alan Loi; Bradley Monk; Steven J. Shabel; Roberto Malinow
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   22
Year:   2018
Pages:   5792
DOI:   10.1073/pnas.1801837115
Publication date:   29-May-2018
Facts, background information, dossiers
  • habenula
  • brain
  • controlling
More about Proceedings of the National Academy of Sciences
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