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Photodynamic therapy is a noninvasive medical procedure in which malignant tissue is damaged by reactive oxygen species generated from targeted light irradiation on a photosensitizer. Herein, we incorporate an Ru(II)-based two-photon photosensitizer into a macrocyclic structure via coordination-driven self-assembly. Properties favorable for photodynamic therapy arise upon formation of the metallacycle, including near-infrared luminescence, strong two-photon absorption, high reactive oxygen species generation efficiency, and selective accumulation in mitochondria and nucleus that are hypersensitive to reactive oxygen species, resulting in good photodynamic therapy efficacy in both in vitro and in vivo investigations. This study shows that supramolecular coordination complexes provide a platform for efficient tuning on the photophysical and biological properties of molecules with biomedical interest.
| Authors: | Zhixuan Zhou; Jiangping Liu; Thomas W. Rees; Heng Wang; Xiaopeng Li; Hui Chao; Peter J. Stang | |
| Journal: | Proceedings of the National Academy of Sciences current issue | |
| Volume: | 115 | |
| edition: | 22 | |
| Year: | 2018 | |
| Pages: | 5664 | |
| DOI: | 10.1073/pnas.1802012115 | |
| Publication date: | 29-May-2018 |
Science and Culture: Math tools send legislators back to the drawing board [Political Sciences]
*UPDATE: On June 18, 2018, after this article went to press, the Supreme Court of the United States ruled on two high-profile cases related to partisan gerrymandering. In effect, the rulings sidestepped the issue of when partisan gerrymandering is unconstitutional. Both cases—one concerning ... more
It is not known whether the fossil content of amber accurately represents the arthropod biodiversity of past forests, and if and how those fossils can be compared with recent fauna for studies and predictions of biodiversity change through time. Our study of arthropods (mainly insects and s ... more
Primary productivity below the seafloor at deep-sea hot springs [Environmental Sciences]
The existence of a chemosynthetic subseafloor biosphere was immediately recognized when deep-sea hot springs were discovered in 1977. However, quantifying how much new carbon is fixed in this environment has remained elusive. In this study, we incubated natural subseafloor communities under ... more
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