My watch list
my.bionity.com  
Login  

Marine Drugs, Vol. 16, Pages 107: Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

Marine Drugs, Vol. 16, Pages 107: Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

Marine Drugs doi: 10.3390/md16040107

Authors: Qing Li Xueqi Sun Guodong Gu Zhanyong Guo

Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating “click reaction” with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL−1) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains.

Authors:   Li, Qing ; Sun, Xueqi ; Gu, Guodong ; Guo, Zhanyong
Journal:   Marine Drugs
Volume:   16
edition:   4
Year:   2018
Pages:   107
DOI:   10.3390/md16040107
Publication date:   28-Mar-2018
Facts, background information, dossiers
  • chitosan
  • water
  • drugs
  • bioactivity
More about Molecular Diversity Preservation International
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE