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Viruses, Vol. 10, Pages 201: Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy

Viruses, Vol. 10, Pages 201: Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy

Viruses doi: 10.3390/v10040201

Authors: Zhongzhong Tu Wenjie Gong Yan Zhang Ye Feng Yan Liu Changchun Tu

The compound 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin present in various plants such as Rhus chinensis Mill and Paeonia suffruticosa, has a broad spectrum of antiviral effects. The present study investigated its potency against infection of mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited virus titers (50-fold), viral mRNA expression (up to 90%), and protein synthesis in vitro. Importantly, we found that PGG not only suppressed viral adsorption and entry, but also directly inactivated RABV through suppression of autophagy by mediating activation of the mTOR-dependent autophagy signaling pathway. In vivo, PGG (10 mg/kg) alleviated the clinical symptoms and reduced the mortality of infected mice by 27.3%. Collectively, our results indicate that PGG has potent anti-RABV effect, and merits further investigation as an anti-RABV drug.

Authors:   Tu, Zhongzhong ; Gong, Wenjie ; Zhang, Yan ; Feng, Ye ; Liu, Yan ; Tu, Changchun
Journal:   Viruses
Volume:   10
edition:   4
Year:   2018
Pages:   201
DOI:   10.3390/v10040201
Publication date:   17-Apr-2018
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