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Synthetic fermentation of bioactive molecules

Publication date:

October 2018

Source:Current Opinion in Chemical Biology, Volume 46

Author(s): Iain A Stepek, Jeffrey W Bode

The concept of synthetic fermentation is to ‘grow’ complex organic molecules in a controlled and predictable manner by combining small molecule building blocks in water—without the need for reagents, enzymes, or organisms. This approach mimics the production of small mixtures of structurally related natural products by living organisms, particularly microbes, under conditions compatible with direct screening of the cultures for biological activity. This review discusses the development and implementation of this concept, its use for the discovery of protease inhibitors, its basis as a chemistry outreach program allowing non-specialists to make and discover new antibiotics, and highlights of related approaches.

Authors:   Author(s): Iain A Stepek, Jeffrey W Bode
Journal:   Current Opinion in Chemical Biology
Volume:   46
Year:   2018
Pages:   18
DOI:   10.1016/j.cbpa.2018.03.014
Publication date:   15-Apr-2018
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