No abstract is available for this article. more
To use all functions of this page, please activate cookies in your browser.
My watch list
my.bionity.com
my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Standardisation of inactivated influenza vaccines – learning from history
Abstract
The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high level of reproducibility and its applicability to the different types of influenza vaccine being produced at that time. Clinical evidence indicated the relevance of SRID as a potency assay. Unique features of the SRID assay are likely responsible for its longevity even as newer technologies for vaccine characterization have been developed and refined. Nevertheless, there are significant limitations to the SRID assay that indicate the need for improvement, and there has been a substantial amount of work undertaken in recent years to develop and evaluate alternative potency assays, including collaborative studies involving research laboratories, regulatory agencies, and vaccine manufacturers. Here, we provide an overview of the history of inactivated influenza vaccine potency testing, the current state of alternative assay development, and the some of the major challenges to be overcome before implementation of new assays for potency determination.
This article is protected by copyright. All rights reserved.
| Authors: | John M Wood, Jerry P Weir | |
| Journal: | Influenza and Other Respiratory Viruses | |
| Year: | 2018 | |
| Pages: | n/a | |
| DOI: | 10.1111/irv.12543 | |
| Publication date: | 21-Jan-2018 |
Facts, background information, dossiers
- Single
- Research
- reproducibility
- longevity
- Determination
- copyright
More about Wiley
-
Publications
1918 pandemic morbidity: the first wave hits the poor, the second wave hits the rich
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... more
The unfolding landscape of the congenital myasthenic syndromes
Abstract Congenital myasthenic syndromes (CMS) are heterogeneous disorders in which the safety margin of neuromuscular transmission is impaired by one or more specific mechanisms. Since the advent of next‐generation sequencing methods, the discovery of novel CMS targets and phenotypes ha ... more
-
News
Smart skin made of recyclable materials may transform medicine and robotics
Smart skin that can respond to external stimuli could have important applications in medicine and robotics. Using only items found in a typical household, researchers have created multi-sensor artificial skin that's capable of sensing pressure, temperature, humidity, proximity, pH, and air ... more
Acetaminophen provides no benefits against the flu
Some doctors may recommend that patients with the flu take acetaminophen, or paracetemol, to relieve their symptoms; however, a new randomized clinical trial found no benefits to the over-the-counter medication in terms of fighting the influenza virus or reducing patients' temperature or ot ... more
Study identifies psychological traits associated with homophobia
A new study that investigated the potential of certain psychological traits for predisposing heterosexuals to have negative attitudes towards homosexual people found that psychoticism - which is present in severe psychopathological conditions but may also contribute to less severe states of ... more
Meistgelesene Fachpublikationen
- 1Use of textile dyeing technology to create an infection‐resistant functionalized polyester biomaterial
- 2Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle
- 3A New Validated HPLC Method for the Determination of Quercetin: Application to Study Pharmacokinetics in Rats
- 4Migration of phthalates from soft PVC packaging into shower and bath gels and assessment of consumer risk
- 5The <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"
- 6GSDS 2.0: an upgraded gene feature visualization server
- 7Dehydration of green beans using ultrasound‐assisted vacuum drying as a novel technique: drying kinetics and quality parameters
- 8Discrimination of Euterpe Oleracea Mart. (Açaí) and Euterpe Edulis Mart. (Juçara) Intact Fruit Using Near‐Infrared (NIR) Spectroscopy and Linear Discriminant Analysis
- 9Particle Size Distribution of Brown and White Rice during Gastric Digestion Measured by Image Analysis
- 10A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray
