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The biopharmaceutical industry is evolving in response to changing market conditions, including increasing competition and growing pressures to reduce costs. Single‐use technologies and continuous bioprocessing have attracted attention as potential facilitators of cost‐optimized manufacturing for monoclonal antibodies. While disposable bioprocessing has been adopted at many scales of manufacturing, continuous bioprocessing has yet to reach the same level of implementation. In this study, the cost of goods of Pall Life Science's integrated, continuous bioprocessing platform was modeled, along with that of purification processes in stainless‐steel and single‐use batch formats. All three models included costs associated with downstream processing only. Evaluation of the models across a broad range of clinical and commercial scenarios revealed that the cost savings gained by switching from stainless‐steel to single‐use batch processing are often amplified by continuous operation. The continuous platform exhibited the lowest cost of goods across 78% of all scenarios modeled here, with the single‐use batch process having the lowest costs in the rest of the cases. The relative savings demonstrated by the continuous process were greatest at the highest feed titers and volumes. These findings indicate that existing and imminent continuous technologies and equipment could become key enablers for more cost effective manufacturing of biopharmaceuticals.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... more
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... more
Smart skin that can respond to external stimuli could have important applications in medicine and robotics. Using only items found in a typical household, researchers have created multi-sensor artificial skin that's capable of sensing pressure, temperature, humidity, proximity, pH, and air ... more
Some doctors may recommend that patients with the flu take acetaminophen, or paracetemol, to relieve their symptoms; however, a new randomized clinical trial found no benefits to the over-the-counter medication in terms of fighting the influenza virus or reducing patients' temperature or ot ... more
A new study that investigated the potential of certain psychological traits for predisposing heterosexuals to have negative attitudes towards homosexual people found that psychoticism - which is present in severe psychopathological conditions but may also contribute to less severe states of ... more