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Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms

Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance (1H NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynecology clinics (cases; n = 176) and healthy control women attending general gynecology clinics (n = 36). Despite high variation in the urine metabolome across the cohort, associations between urine metabolic profiles and BMI, parity, overactive bladder syndrome, frequency, straining, and bladder storage were identified using KODAMA (knowledge discovery by accuracy maximization). Four distinct urinary metabotypes were identified, one of which was associated with increased urinary frequency and low B...

Authors:   Rhiannon Bray; Stefano Cacciatore; Beatriz Jiménez; Rufus Cartwright; Alex Digesu; Ruwan Fernando; Elaine Holmes; Jeremy K. Nicholson; Phillip R. Bennett; David A. MacIntyre; Vik Khullar
Journal:   Journal of Proteome Research
Year:   2017
DOI:   10.1021/acs.jproteome.7b00568
Publication date:   04-Oct-2017
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