Highlights from Recent Cancer Literature

Antibody-Drug Conȷugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrrolobenzodiazepine dimer (PBD) or tubulysin p ... more

Correction: Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells

In this article [(Cancer Res 2016;76:5756–67)][1], which appeared in the October 1, 2016, issue of Cancer Research ([1][2]), there are errors in Figs. 2A and 6E. The authors used one trimmed image/blot to fit the size of the others. In these two panels, they accidentally kept the “ruler image/ more

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3K{delta}/{gamma}

Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell–inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. He ... more

Investigational KW-0761 efficiently depletes immune system-suppressing Treg cells

In a phase Ia clinical trial, immune cells called Tregs, which can inhibit anticancer immune responses, were efficiently eliminated from the blood of patients with lung or esophageal cancer by treatment with the investigational therapeutic antibody KW-0761. Author(s): Ryuzo Ueda, MD, PhD, p ... more