No abstract is available for this article. more
To use all functions of this page, please activate cookies in your browser.
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
To assess the effect of policy interventions, i.e. reimbursement decisions, guidelines, and regional recommendations, on the prescribing of oral anticoagulant treatment in patients with atrial fibrillation (AF).Methods
Interrupted time series analyses using monthly data on all patients with a recorded diagnosis of AF newly initiated (both switchers and anticoagulant naïve patients) on either warfarin, dabigatran, rivaroxaban or apixaban in the Stockholm region from April 2011 until February 2016.Results
A total of 34 165 initiations in 27 942 patients were included. The publication of the European Guidelines was associated with an increase in Novel Oral Anticoagulant (NOAC) initiations of 12.5% (95% confidence interval (CI): 7.3;17.7) after 5 months. The choice between the different NOACs was mainly associated with changes in the regional recommendations with apixaban initiations increasing by 19.5% (95% CI: 16.3;22.7) 5 months after the drug was recommended as a first‐line alternative to warfarin. Dabigatran received a second‐line recommendation but decreased by ‐9.5% (95% CI: ‐12.6;‐6.4) and rivaroxaban which had no specific recommendation decreased by ‐9.2% (95% CI: ‐12.7;‐5.7%). A steady decrease in warfarin and increase in NOAC initiations was seen throughout the study period and from November 2015, AF patients were more likely to receive apixaban than any other anticoagulant, while less than 20% of the initiations were with warfarin.Conclusions
After reimbursement and inclusion in the European guidelines the NOACs started gaining popularity, while changes in regional recommendations were associated with the biggest change in the prescriber's choice between the different NOACs. This article is protected by copyright. All rights reserved.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... more
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... more
Smart skin that can respond to external stimuli could have important applications in medicine and robotics. Using only items found in a typical household, researchers have created multi-sensor artificial skin that's capable of sensing pressure, temperature, humidity, proximity, pH, and air ... more
Some doctors may recommend that patients with the flu take acetaminophen, or paracetemol, to relieve their symptoms; however, a new randomized clinical trial found no benefits to the over-the-counter medication in terms of fighting the influenza virus or reducing patients' temperature or ot ... more
A new study that investigated the potential of certain psychological traits for predisposing heterosexuals to have negative attitudes towards homosexual people found that psychoticism - which is present in severe psychopathological conditions but may also contribute to less severe states of ... more