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Publication date: Available online 30 June 2018 Source:Computational Biology and Chemistry Author(s): Ikrormi Rungsung, Muthukumaran Rajagopalan, Amutha Ramaswamy LKB1 protein is involved in the regulation of cell polarity by phosphorylating the AMPK under energetic stress condi ... more
Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave rea ... more
Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Adrienn Kazsoki, Attila Domján, Károly Süvegh, Romána Zelkó Papaverine hydrochloride loaded gels, films and electrospun fibers were prepared for buccal drug delivery w ... more
Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes Pericytes are perivascular cells that play important roles in the regulation of the blood-brain barri ... more
Energies, Vol. 11, Pages 1703: Modelling Uncertainty in t-RANS Simulations of Thermally Stratified Forest Canopy Flows for Wind Energy Studies Energies doi: 10.3390/en11071703 Authors: Cian J. Desmond Simon Watson Christiane Montavon Jimmy Murphy The flow over densely fo ... more
Publication date: Available online 30 June 2018 Source:Computational Biology and Chemistry Author(s): Ikrormi Rungsung, Muthukumaran Rajagopalan, Amutha Ramaswamy LKB1 protein is involved in the regulation of cell polarity by phosphorylating the AMPK under energetic stress condi ... more
Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2O2) ... more
RNAi has revolutionized genetic research, and is being commercialized as an insect pest control technology. Mechanisms exploited for this purpose are antiviral and therefore rapidly evolving. Ideally, RNAi will also be used for noninsect pests; however, differences in RNAi biology make this ... more
The Microprocessor complex, consisting of an RNase III DROSHA and the DGCR8 dimer, cleaves primary microRNA transcripts (pri-miRNAs) to initiate microRNA (miRNA) maturation. Pri-miRNAs are stem–loop RNAs, and ~79% of them contain at least one of the three major and conserved RNA motifs, UG, ... more
MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at ... more
Abstract Objective Screening via non‐invasive prenatal testing (NIPT) involving the analysis of cell‐free DNA (cfDNA) from plasma has become readily available to screen for chromosomal and DNA aberrations through maternal blood. This report reviews a laboratory's experience with follow ... more
Abstract Objective To determine how frequently and effectively products of conception can be obtained among women pursuing medical management of early pregnancy loss. Methods This pilot study was conducted to assess products of conception recovery outcomes for participants optin ... more
Abstract Objective During human pregnancy, the DNA methylation of placental tissue is highly relevant to the normal growth and development of the fetus, therefore methylomic analysis of the placental tissue possesses high research and clinical value in prenatal testing and monitoring. ... more
Abstract Objective Fetal aortic stenosis (AS) imposes pressure load on the developing left ventricle (LV) and leads to derangements in myocardial structure and function via mechanisms that are not well characterized. Methods We compared amniotic fluid NT‐BNP and troponin levels ... more
Abstract Objectives Chromosomal microarray (CMA) analysis is effectively applied prenatally to detect copy number changes. SNP probes included in the microarray platform can detect regions of excessive homozygosity (ROH) and identical‐by‐descent genomic stretches. The utility of the la ... more
We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ... more
We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ... more
Atherosclerosis is the most common cause of heart disease and stroke. The use of animal models has advanced our understanding of the molecular signaling that contributes to atherosclerosis. Further understanding of this degenerative process in humans will require human tissue. Plaque remove ... more
Transforming growth factor-β (TGF-β) plays a central role in hepatic fibrogenesis. This study investigated the function and mechanism of bone morphogenetic protein-2 (BMP-2) in regulation of hepatic fibrogenesis. BMP-2 expression in fibrotic liver was measured in human tissue microarray and ... more
As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and t ... more
Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave rea ... more
Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Adrienn Kazsoki, Attila Domján, Károly Süvegh, Romána Zelkó Papaverine hydrochloride loaded gels, films and electrospun fibers were prepared for buccal drug delivery w ... more
Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes Pericytes are perivascular cells that play important roles in the regulation of the blood-brain barri ... more
Marine Drugs, Vol. 16, Pages 222: Physicochemical Properties and Biocompatibility Evaluation of Collagen from the Skin of Giant Croaker (Nibea japonica) Marine Drugs doi: 10.3390/md16070222 Authors: Yunping Tang Shujie Jin Xiaoyan Li Xiaojuan Li Xuyang Hu Yan Chen Fangfa ... more
Marine Drugs, Vol. 16, Pages 223: Elucidation of the Relationship between CD Cotton Effects and the Absolute Configuration of Sixteen Stereoisomers of Spiroheterocyclic-Lactams Marine Drugs doi: 10.3390/md16070223 Authors: Takeshi Yamada Tetsuya Kajimoto Takashi Kikuchi Reiko ... more
by Miguel Rodríguez Pulido, María Teresa Sánchez-Aparicio, Encarnación Martínez-Salas, Adolfo García-Sastre, Francisco Sobrino, Margarita Sáiz The RNA helicase LGP2 (Laboratory of Genetics and Physiology 2) is a non-signaling member of the retinoic acid-inducible gene-I (RIG-I)-like recep ... more
by Richard K. Plemper, Robert M. Cox more
by Kathrin K. Geyer, Sabrina E. Munshi, Helen L. Whiteland, Narcis Fernandez-Fuentes, Dylan W. Phillips, Karl F. Hoffmann While schistosomiasis remains a significant health problem in low to middle income countries, it also represents a recently recognised threat to more economically-deve ... more
by Nicolás Cifuentes-Muñoz, Rebecca Ellis Dutch, Roberto Cattaneo more
by Lindsay McDonald, Mathieu Cayla, Alasdair Ivens, Binny Mony, Paula MacGregor, Eleanor Silvester, Kirsty McWilliam, Keith R. Matthews Trypanosoma brucei, the agents of African trypanosomiasis, undergo density-dependent differentiation in the mammalian bloodstream to prepare for transmis ... more
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