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27 Current news about the topic transgenic mice


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A sprinkle of platinum nanoparticles onto graphene makes brain probes more sensitive


Graphene electrodes could enable higher quality imaging of brain cell activity thanks to new research by a team of engineers and neuroscientists at the University of California San Diego. The researchers developed a technique, using platinum nanoparticles, to lower the impedance of graphene ...


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Transplanted hematopoietic stem cells reverse damage caused by neuro-muscular disorder


Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease. The findings suggest ...


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Watching the luminescent gene switch


"Clock genes" turn on and off, or "Express", in rhythmic patterns throughout the body to regulate physiological conditions and behaviour. When and how these genes express, especially in tissues outside the brain, is still poorly understood. Until now, scientists have lacked sufficient means to ...


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Live-imaging technique for mice seen as boost to studies of brain function and development

Scientists capture brain-wide view of neural activity


University of Oregon scientists have looked into the brains of living mice to see in real time the processing of sensory information and generation of behavioral responses. To do so, researchers developed a line of transgenic mice whose brains expressed a green fluorescent protein that lights up ...


Cyclin D1 governs microRNA processing in breast cancer

Cyclin D1 controls cell cycle progression and microRNA biogenesis through Dicer -- a new mechanism promoting breast cancer


Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA), according to new research in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the ...


Recombinant human prion protein inhibits prion propagation


Case Western Reserve University researchers published findings that point to a promising discovery for the treatment and prevention of prion diseases, rare neurodegenerative disorders that are always fatal. The researchers discovered that recombinant human prion protein stops the propagation of ...


High levels of a specific enzyme in fetuses linked to anxiety


Mouse embryos with the human enzyme CYP2C19 in the brain develop a smaller hippocampus and anxiety-like behaviour as adults. The results of this new study, which is published in the journal Molecular Psychiatry, agree in principle with earlier genetic findings in humans, and can improve science’s ...


Crescendo announces the Crescendo Mouse

Technology generates superior human single domain antibody VH fragments in a transgenic mouse


Crescendo Biologics Limited announces the Crescendo Mouse, an antibody fragment technology which allows the generation of human single domain antibody VH fragments from a transgenic mouse. VH fragments are antibody-based therapeutic proteins that have applications beyond the scope of full length ...


Peripheral Induction of Alzheimer-Like Brain Pathology in Mice


Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain. This is shown in a new study done ...


Jasmine as valium substitute: researchers discover unexpected effect of scents

Effect is comparable to potent psychotropic drugs


Instead of a sleeping pill or a mood enhancer, a nose full of jasmine from Gardenia jasminoides could also help: in collaboration with Dr. Olga Sergeeva and Prof. Helmut Hass from the Heinrich Heine University in Düsseldorf, researchers from Bochum led by Prof. Dr. Dr. Dr. Hanns Hatt have ...


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