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77 Current news about the topic kinases

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'Druggable' cancer target found in pathway regulating organ size

Finding caps more than a decade of research on 'Hippo' pathway

21-Nov-2018

It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. It's further known that a major player in this pathway, YAP, drives many types of tumors. Now, researchers at Boston Children's ...

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Newly discovered enzyme is 'firing pin' for plant immunity

19-Sep-2018

Just like humans, plants have an immune system that helps them fight off infections. Plant immunity has some important differences: they don't make antibodies and can't fight off the same bug more quickly months or years later. However, plant cells can identify pathogens and react to them, often ...

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Enzyme's movement may be key to new cancer drugs

17-May-2018

Revealing all the steps required to activate an enzyme called a protein kinase may identify new ways to target cancer, according to new University of Arizona-led research. Not only must the kinase have all needed parts in place, the enzyme must move in the correct manner and at the correct speed ...

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New insights into how your brain keeps its balance

23-Jan-2018

As with all things in life, healthy brain function depends on a balance of forces. We think of our brains as active - moving a leg and saying a word are all "active" events. But it is just as important for our brains to be able to stop these actions -to stop our leg, and to stop our speech. But ...

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New breast cancer drug defeats the Ras genes notorious for causing many types of cancer

13-Oct-2017

Blocking the function of the Ras oncogenes is considered by many scientists to be the "holy grail" of cancer therapeutics because mutations in these genes drive the growth of so many different types of cancers. The three Ras genes found in humans -- H-Ras, K-Ras and N-Ras --were among the first ...

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The fork in the road to DNA repair

13-Jul-2017

The human body consists of trillions of cells, and within each are billions of DNA molecules. Strict maintenance of the molecules is essential to maintain a healthy cell and thus a healthy body. This maintenance is challenged by the daily bombardment of chemicals, UV light, radical oxgen and ...

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Spotting the invisible

Mapping structures and functions of a transient enzyme state

02-Jun-2017

Chemists at Umeå University have succeeded in mapping structures and functions of a transient enzyme state. By modifying the enzyme adenylate kinase, researchers were able to isolate the molecule and study it using the quantitative techniques X-ray crystallography and nuclear magnetic resonance ...

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Biophysicists say iodine is the solution of biomolecule structures

18-May-2017

An international team including researchers from MIPT has shown that iodide phasing--a long-established method in structural biology--is universally applicable to membrane protein structure determination. Knowledge of these structures enables a molecular-level understanding of the workings of ...

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New hope in the fight against superbugs

05-May-2017

Antibiotic resistance is a growing global health threat. So much so that a 2014 study commissioned by the Prime Minister of the United Kingdom predicted that, if the problem is left unchecked, in less than 35 years more people will die from antibiotic resistant superbugs than from cancer. It is ...

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First complete interactome map of human receptor tyrosine kinases and phosphatases

09-Jan-2017

In 2011, Igor Stagljar, a professor in the University of Toronto's Donnelly Centre, came across a study that genetically linked two genes in the cell to a hard-to-treat (triple negative) breast cancer. It was not clear how the proteins encoded by these genes worked, but Stagljar had a unique way ...

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