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31-Jul-2017 - Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA. A team of researchers at the University of California San Diego School of Medicine and the Salk Institute for Biological Studies describe development and application of new electron ...
30-Mar-2017 - Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo. Using ...
Scientists measure molecular forces between nucleosomes
27-Feb-2017 - The genome molecule contains the blueprint for life. The manner in which the blueprint is packed into the cell determines which genes are active and which are set to inactive. Disturbing this structure can result in illnesses such as cancer. Munich scientists have now succeeded in using molecular ...
21-Feb-2017 - Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques. Vadim Backman and Hao Zhang, nanoscale ...
30-Jun-2016 - "Interphase" refers to the period in the cell cycle in which chromosomes spend most of their time. During this phase, in between mitoses, chromosomes live "dissolved'' in the nucleus where they carry out the processes required for the duplication of genetic material. Our current knowledge ...
23-Jun-2016 - Despite the enormous societal impact of chronic pain, present treatment options are limited to nonsteroidal anti-inflammatory drugs (NSAIDS), opioids, anticonvulsants and antidepressants, which provide pain relief to only about half of patients. Furthering the problem, prescription opioid ...
17-May-2016 - A mutation that affects the proteins that package DNA--without changing the DNA itself--can cause a rare form of cancer, according to new findings from researchers at The Rockefeller University . The mutation is present in histones, the protein scaffolding around which DNA wraps. Researchers have ...
20-Apr-2016 - If genes form the body's blueprint, then the layer of epigenetics decides which parts of the plan get built. Unfortunately, many cancers hijack epigenetics to modulate the expression of genes, thus promoting cancer growth and survival. A team of researchers led by Tatiana Kutateladze, PhD, ...
16-Feb-2016 - A team of scientists in Japan has found that a DNA modification called 5hmC - thought to be involved in turning genes on and off - localizes at sites of DNA damage and repair. They also found that a family of recently discovered enzymes, called TETs for short, is important in maintaining 5hmC's ...
09-Feb-2016 - Stress in the body’s cells is both the cause and consequence of inflammatory diseases or cancer. The cells react to stress to protect themselves. Researchers at the University of Zurich have now developed a new technique that allows studying a fundamental response to stress in much more detail ...
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