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14-Aug-2019 - CureVac AG announced it has entered into a Collaborative Research Agreement (“CRA”) with Yale University for discovery research into mRNA-based pulmonary therapeutic candidates. The exclusive CRA covers the development of an undisclosed number of novel mRNA-based candidates for pulmonary ...
09-Oct-2018 - By severely curtailing the effects of antibiotics, the formation of organized communities of bacterial cells known as biofilms can be deadly during surgeries and in urinary tract infections. Yale researchers have just come a lot closer to understanding how these biofilms develop, and potentially ...
17-Jul-2018 - Yale is adding microscopy that provides an unprecedented view of specimens whose thickness had thwarted close inspection Biological structures exist and function in three dimensions, but the limitations of imaging technology have long meant that scientists could examine only two dimensions in ...
05-Jul-2018 - Obesity, which is on the rise worldwide, has been linked to colon cancer but the mechanism has been a mystery. In a new study, Yale researchers and their co-authors have uncovered how obesity drives tumor growth in mice, revealing potential strategies to combat the disease. Led by assistant ...
28-Jun-2018 - With the combined efforts of three Yale laboratories, researchers conducted the first demonstration of site-specific gene editing in a fetus, correcting a mutation that causes a severe form of anemia. The technique, described in a paper published June 26 in Nature Communications, involves an ...
New approach to glycosylation that is remarkably simple and works in water at room temperature
03-May-2018 - In the world of chemistry, good things can happen if you just add sugar. A wide range of drugs and biochemical probes -- everything from antibiotics to Alzheimer's disease biomarkers -- rely on natural or synthetic compounds that aid a reaction by adding carbohydrates. It's a process called ...
02-Feb-2018 - Building on prior research that examined the use of an arthritis medication to treat vitiligo, a team of Yale dermatologists has successfully applied a novel combination therapy -- the medication and light -- to restore skin color in patients. Associate professor of dermatology Brett King, ...
14-Dec-2017 - A small-molecule inhibitor tested by researchers at Yale and Stanford may be the answer to blocking the spread of harmful mosquito-borne pathogens, including Zika and dengue viruses, according to a new study. The molecule, dubbed NGI-1, was identified by co-author Joseph Contessa, M.D., an ...
13-Nov-2017 - Two new research papers reinforce the benefits of a novel therapy that hijacks the cell’s own protein degradation machinery to destroy cancer cells, Yale researchers report Nov. 9 in the journal Cell Chemical Biology. The new approach to drug discovery, called Proteolysis Targeting Chimeras or ...
Neutralization of pathogenic fungi with small-molecule immunotherapeutics
25-Sep-2017 - Fungal infections represent an increasing health crisis, especially for immune-deficient patients. Scientists report that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action. They developed small bifunctional molecules that simultaneously bind both ...
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