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CureVac Enters into an Exclusive Collaborative Research Agreement with Yale University

14-Aug-2019

CureVac AG announced it has entered into a Collaborative Research Agreement (“CRA”) with Yale University for discovery research into mRNA-based pulmonary therapeutic candidates. The exclusive CRA covers the development of an undisclosed number of novel mRNA-based candidates for pulmonary ...

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How fatal biofilms form

09-Oct-2018

By severely curtailing the effects of antibiotics, the formation of organized communities of bacterial cells known as biofilms can be deadly during surgeries and in urinary tract infections. Yale researchers have just come a lot closer to understanding how these biofilms develop, and potentially ...

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Seeing how cells work as never before

17-Jul-2018

Yale is adding microscopy that provides an unprecedented view of specimens whose thickness had thwarted close inspection Biological structures exist and function in three dimensions, but the limitations of imaging technology have long meant that scientists could examine only two dimensions in ...

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How obesity drives colon cancer in mice

05-Jul-2018

Obesity, which is on the rise worldwide, has been linked to colon cancer but the mechanism has been a mystery. In a new study, Yale researchers and their co-authors have uncovered how obesity drives tumor growth in mice, revealing potential strategies to combat the disease. Led by assistant ...

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With gene editing, researchers cure blood disorder in fetal mice

28-Jun-2018

With the combined efforts of three Yale laboratories, researchers conducted the first demonstration of site-specific gene editing in a fetus, correcting a mutation that causes a severe form of anemia. The technique, described in a paper published June 26 in Nature Communications, involves an ...

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A new formula for creating chemical reactions -- with carbs

New approach to glycosylation that is remarkably simple and works in water at room temperature

03-May-2018

In the world of chemistry, good things can happen if you just add sugar. A wide range of drugs and biochemical probes -- everything from antibiotics to Alzheimer's disease biomarkers -- rely on natural or synthetic compounds that aid a reaction by adding carbohydrates. It's a process called ...

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Vitiligo treated successfully with arthritis drug and light therapy

02-Feb-2018

Building on prior research that examined the use of an arthritis medication to treat vitiligo, a team of Yale dermatologists has successfully applied a novel combination therapy -- the medication and light -- to restore skin color in patients. Associate professor of dermatology Brett King, ...

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Drug blocks Zika and dengue viruses in study

14-Dec-2017

A small-molecule inhibitor tested by researchers at Yale and Stanford may be the answer to blocking the spread of harmful mosquito-borne pathogens, including Zika and dengue viruses, according to a new study. The molecule, dubbed NGI-1, was identified by co-author Joseph Contessa, M.D., an ...

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Cellular clean-up can also sweep away forms of cancer

13-Nov-2017

Two new research papers reinforce the benefits of a novel therapy that hijacks the cell’s own protein degradation machinery to destroy cancer cells, Yale researchers report Nov. 9 in the journal Cell Chemical Biology. The new approach to drug discovery, called Proteolysis Targeting Chimeras or ...

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Steering the Immune Defense against Fungal Pathogens

Neutralization of pathogenic fungi with small-molecule immunotherapeutics

25-Sep-2017

Fungal infections represent an increasing health crisis, especially for immune-deficient patients. Scientists report that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action. They developed small bifunctional molecules that simultaneously bind both ...

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