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Pharmaceutical Production with Reduced Waste

Platform technology for producing cephalosporin antibiotics

18-Jun-2019

Antibiotics save countless human lives – modern medicine without them is unimaginable. The largest proportion by volume of industrially produced antibiotics today are cephalosporins, structural variants of the first antibiotic, penicillin. Unfortunately, their production generates a considerable ...

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For a Better Contrast

Rare earth orthoferrite LnFeO3 nanoparticles for bioimaging

06-Sep-2018

Magnetic resonance imaging (MRI) has emerged as one of the most powerful clinical imaging tools because of its superb spatial resolution and soft tissue contrast, especially when using contrast agents. In the European Journal of Inorganic Chemistry, scientists have presented a new kind of ...

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Garlic ingredient from the lab bench

Total synthesis of ajoene, a biologically active component in oil extracts of garlic

24-Aug-2018

Fresh garlic extracts contain a variety of healthy organosulfur compounds, among which ajoene forms a major oil-extractable ingredient. Now, chemists in the United Kingdom have synthesized ajoene from readily available components for the first time. The results show that ajoene is accessible on a ...

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Two new ways to fluorinated structures

Chemo-enzymatic synthesis of fluorinated antibiotics

07-Aug-2018

Fluorinated structures make up more than 20 percent of modern drugs, but benign and fast fluorination schemes are scarce. In a study scientists have now combined dynamic kinetic resolution and nucleophilic fluorination for the asymmetric synthesis of florfenicol, a veterinary antibiotic. After ...

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Combination Pack Battles Cancer

Nanoparticles with multifunctional drug precursor for synergistic tumor therapy

01-Jun-2018

For efficient cancer therapy with few side effects, the active drug should selectively attain high concentration in the tumor. Scientists have now introduced a new approach, in which two synergistic drug components are combined into a dimer. This dimer can be incorporated into polymeric ...

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Libraries for Proteins

Dynamic combinatorial libraries generated from hydrazone-functionalized surface mimetics

29-May-2018

Combinatorial libraries are a key component of the chemist's toolkit for ligand screening. Dynamic combinatorial libraries add a new dimension by interlinking synthesis and screening. Now, British scientists have developed a dynamic combinatorial library for the screening of supramolecular ligand ...

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Wood to Supercapacitors

Electrode materials from ultrathin carbon nanofiber aerogels derived from cellulose

25-May-2018

Carbon aerogels are ultralight, conductive materials, which are extensively investigated for applications in supercapacitor electrodes in electrical cars and cell phones. Chinese scientists have now found a way to make these electrodes sustainably. The aerogels can be obtained directly from ...

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Controlled Nano-Assembly

Universal pH regulated assembly of DNA nanostructures

24-May-2018

DNA, the carrier of genetic information, has become established as a highly useful building material in nanotechnology. One requirement in many applications is the controlled, switchable assembly of nanostructures. Scientists have now introduced a new strategy for control through altering pH ...

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Multifunctional platform for the delivery of gene therapeutics

Thermo-triggered release of a genome-editing machinery by modified gold nanoparticles

24-Jan-2018

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the “gene scissors” to the tumor cell genome. As the authors report, their nonviral transport and release platform of gene-editing ...

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Lifesaving Microbubbles

Stable, self-disrupting microbubbles as intravenous oxygen carriers

24-Jan-2018

Severe oxygen deficiency eventually leads to cardiac arrest. If the blood’s oxygen content cannot be rapidly re-established, the patient may die within minutes. American scientists have introduced air-filled microbubbles that could be used as an intravenous oxygen carrier to increase the survival ...

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