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How to quell a cytokine storm: New ways to dampen an overactive immune system

Penn Medicine, University of Leeds findings have implications for new drug targets for lupus, other autoimmune disorders

03-Jun-2019

BRCA--the family of DNA-repair proteins associated with breast, ovarian, prostate, and pancreatic cancers--interacts with a multipart, molecular complex that is also responsible for regulating the immune system. When certain players in this pathway go awry, autoimmune disorders, like lupus, can ...

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Decoding Lil BUB: Crowdfunded project reveals genome of internet celebrity cat

06-Mar-2019

Lil BUB has drawn millions of followers across the internet for her cute appearance. Behind the celebrity cat’s unique features is a combination of two rare genetic variants, three molecular biologists from Germany and the US report. The results of their crowdfunded project “LilBUBome” are now ...

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Global trial shows CAR T therapy can lead to durable remissions in non-Hodgkin's lymphoma

04-Dec-2018

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL). ...

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Genetic variants reveal new targets for chronic kidney disease treatment

How specific cell types can lead to development of disease

04-Oct-2018

The kidney does more than double or even triple duty compared to other organs - it extracts waste, balances body fluids, forms urine, regulates blood pressure, and secretes hormones. Given this complexity, when things go wrong, havoc can ensue, causing a suite of symptoms called chronic kidney ...

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Gene-editing reduces triglycerides, cholesterol by up to 50 percent

CRISPR-like technique in animal study offers clues to mimic protective genetic mutations

01-Mar-2018

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks, according to new mouse research from the Perelman School of Medicine at the University of ...

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Testing drug transfer using placenta-on-a-chip

20-Feb-2018

Researchers at the University of Pennsylvania's School of Engineering and Applied Science have demonstrated the feasibility of their "organ-on-a-chip" platform in studying how drugs are transported across the human placental barrier. Some maternally-administered medications can enter the fetal ...

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New treatment target for melanoma identified

18-Jan-2018

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a ...

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Super-silenced DNA hints at new ways to reprogram cells

09-Jan-2018

Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study by investigators from the Perelman School of Medicine at the University of Pennsylvania. "In the past, most ...

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First DNA sequence from a single mitochondria

08-Dec-2017

DNA sequences between mitochondria within a single cell are vastly different, found researchers in the Perelman School of Medicine at the University of Pennsylvania. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in ...

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Mistakes in how proteins of the ear are built contribute to early hearing loss

30-Oct-2017

From the moment a baby is born, they are put through a battery of screenings to test for all sorts of characteristics, which includes the sense of hearing. One in 500 newborns fail their newborn hearing screens and are diagnosed with hearing loss, making this the most prevalent sensory deficit in ...

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