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Bid to beat superbugs boosted by immune defence discovery

04-Jun-2019

The fight against superbugs could be helped by the discovery of a potential therapy based on the body's natural immune defences. Scientists have found that a molecule produced by the body - called LL-37 - changes the way cells behave when they are invaded by bacteria. The molecule acts like a ...

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Tracking Small Things in Cells

Small and tunable fluorophores for the imaging of metabolites in living cells

02-May-2019

Living cells can react to disturbances with a changed metabolism, but direct observation of trafficking metabolites in live cells is difficult. An international team of scientists has now developed a class of remarkably small fluorophores called SCOTfluors. The dyes emit light in the visible to ...

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DNA is managed like climbers' rope to help keep tangles at bay

24-Apr-2019

A process that cells use to unravel knotted strands of DNA - resembling a method used to control climbing ropes - has been uncovered by scientists. The findings help explain how about 2 metres of DNA can be neatly packaged in each of our cells, in a space that is about the width of a ...

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Spying on cells eating habits could aid cancer diagnosis

09-Apr-2019

Scientists have developed a new imaging technology to visualise what cells eat, which could aid the diagnosis and treatment of diseases such as cancer. The team has designed chemical probes that light up when they attach to specific molecules that cells eat, such as glucose. Researchers used ...

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Nano-scale process may speed arrival of cheaper hi-tech products

12-Nov-2018

An inexpensive way to make products incorporating nanoparticles - such as high-performance energy devices or sophisticated diagnostic tests - has been developed by researchers. The process could speed the commercial development of devices, materials and technologies that exploit the physical ...

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DNA study casts light on century-old mystery of how cells divide

22-Jan-2018

Scientists have solved a longstanding puzzle of how cells are able to tightly package DNA to enable healthy cell division. Their findings shed light on how single cells can compact DNA 10,000-fold to partition it between two identical cells - a process that is essential for growth, repair and ...

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A genetic timetable of brain's aging process

12-Sep-2017

The programme controls how and when brain genes are expressed at different times in a person's life to perform a range of functions, the study found. Experts say the timing is so precise that they can tell the age of a person by looking at the genes that are expressed in a sample of brain ...

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Zebrafish study reveals clues to healing spinal cord injuries

26-Jul-2017

Fresh insights into how zebrafish repair their nerve connections could hold clues to new therapies for people with spinal cord injuries. Researchers have pinpointed key molecules that prompt damaged nerve fibres in the fish to regenerate themselves. The findings could pave the way for treatments ...

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Paracetamol study could open door for way to treat liver damage

02-Feb-2017

Scientists have shed new light on how the common painkiller paracetamol causes liver damage. Their findings may offer valuable insights into poisoning caused by an excess dose, which can be difficult to treat and may prove fatal. The discovery could inform research into therapies to counteract ...

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Parkinson's study could pave way for early detection test

30-Aug-2016

A test that can detect Parkinson's disease in the early stages of the illness has moved a step closer. Scientists have developed a way of detecting a molecule linked to the condition in samples of spinal fluid from patients. Experts say that the test needs to be validated with a larger sample ...

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