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Microscopy Deep Learning Predicts Viral Infections

Automatic detection of virus-infected cells - solely on the fluorescence of the cell nucleus


When viruses infect cells, changes in the cell nucleus occur, and these can be observed through fluorescence microscopy. Using fluoresence images from live cells, researchers at the University of Zurich have trained an artificial neural network to reliably recognize cells that are infected by ...


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Cholesterol Levels Sustainably Lowered Using Base Editing

Potential therapy for patients with inherited metabolic liver diseases


Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team led by the University of Zurich has succeeded in sustainably lowering high LDL cholesterol ...


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New Technology Makes Tumor Eliminate Itself

Trojan horse to deliver genes for cancer therapeutics directly into tumor cells


A new technology developed by UZH researchers enables the body to produce therapeutic agents on demand at the exact location where they are needed. The innovation could re-duce the side effects of cancer therapy and may hold the solution to better delivery of Covid-related therapies directly to ...


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Biomarker Detects Severe COVID-19 Early On

SARS-CoV-2-specific immune signature deciphered


Severe cases of COVID-19 can now be detected at an early stage. Researchers at the University of Zurich have identified the first biomarker that can reliably predict which patients will develop severe symptoms. This can help to improve the treatment of severe cases of COVID-19. Most people who ...


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Defective Epithelial Barriers Linked to Two Billion Chronic Diseases

Rise in allergic and autoimmune conditions


Humans are exposed to a variety of toxins and chemicals every day. According to the epithelial barrier hypothesis, exposure to many of these substances damages the epithelium, the thin layer of cells that covers the surface of our skin, lungs and intestine. Defective epithelial barriers have been ...


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The First Comprehensive Single-Cell Atlas of Human Teeth

The dental pulp and periodontium are susceptible to caries and periodontitis and contain stem cells that have great regenerative potential


Researchers at the University Zurich have mapped the first complete atlas of single cells that make up the human teeth. Their research shows that the composition of human dental pulp and periodontium vary greatly. Their findings open up new avenues for cell-based dental therapeutic ...


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Consumption of Added Sugar Doubles Fat Production

Too much sugar is unhealthy – that we know, but it’s not just down to the many calories


Even moderate amounts of added fructose and sucrose double the body’s own fat production in the liver, researchers from the University of Zurich have shown. In the long term, this contributes to the development of diabetes or a fatty liver. Sugar is added to many common foodstuffs, and people in ...


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Reactivating Aging Stem Cells in the Brain

With increasing age, and in patients suffering from Alzheimer’s disease, the hippocampus’ ability to create new neurons declines steadily – and with it, its memory functions


As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers at the University of Zurich have now discovered a mechanism linked to stem cell aging – and how the production of neurons can be ...


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Smartphone App to Change Your Personality

Can personality traits such as openness, conscientiousness, or sociability be psychologically influenced in a short-term and targeted manner?


How quickly can personality traits be modified? An international research team led by the University of Zurich has shown that daily use of a smartphone app can lead to desired personality changes within three months. And three months after the daily interventions, the changes are still ...


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1918 Pandemic Second Wave Had Fatal Consequences

History repeats itself


In the event of a pandemic, delayed reactions and a decentralized approach by the authorities at the start of a follow-up wave can lead to longer-lasting, more severe and more fatal consequences, researchers from the universities of Zurich and Toronto have found. The interdisciplinary team ...


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