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Liver cancer: How liver cells go astray

Major changes in cell metabolism


Liver cancer is one of the most deadly types of cancer. A team of University of Basel researchers has now uncovered how a healthy liver cell turns into a tumor cell. Comprehensive metabolic changes convert mature liver cells into immature progenitor cells. These cells proliferate rapidly and ...


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How an Emerging Drug Class Dampens Harmful Immune Reactions

It wasn't until 2021 that a new therapy came on the market, in the form of a class of drugs called compstatins, to inhibit harmful immune responses of the complement system


Although the complement system forms part of the innate immune system, it can cause damage to the body in some cases. This is because unwanted complement activation contributes to many autoimmune and chronic inflammatory diseases. Now, researchers have described molecular details of a recently ...


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How Covid-19 Causes Neurological Damage

Holes in the blood-brain barrier


Although the coronavirus known as SARS-CoV-2 does not infect nerve cells, it can cause damage to the nervous system. Researchers from the University of Basel and University Hospital Basel have studied the mechanisms responsible for this effect, known as “neuro-Covid”, and identified starting ...


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Sugar molecules as a target in cancer therapy

How immune cells turn traitor


Cancer cells use sugar molecules on their surface to disable attacks by the body’s immune system. Researchers at the University of Basel now report on how this mechanism can be neutralized. The immune system is actually extremely well equipped to get rid of abnormal cells. As a safety mechanism, ...


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Discovery of a new antibiotic against resistant pathogens

A boost for antibiotics research


For a long time, antibiotics were considered a silver bullet against bacterial infections. Over time, many pathogens have adapted to resist antibiotics, so the search for new drugs is becoming increasingly important. An international team of researchers including scientists at the University of ...


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Researchers turn cancer cells into less harmful cell types

The results open a new avenue for treating triple-negative breast cancer


Cancer cells resemble stem cells in being extremely adaptable. University of Basel researchers have identified compounds that artificially mature breast cancer cells of the highly aggressive triple negative subtype and convert them to a state that resembles normal cells. Cancer occurs when cells ...


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Insufficient insulin processing leads to overweight

The finding opens up new therapeutic possibilities


Overweight increases the risk of an imbalance in sugar metabolism and even of diabetes. A research group at the University of Basel has now shown the opposite is true as well: deficits in the body’s insulin production contribute to overweight. Poor nutrition, too little movement and too many ...


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High-speed storage of CO2 discovered in bacteria


The steadily worsening climate crisis caused by the accumulation of carbon dioxide (CO2) in the atmosphere makes the search for ideas to store CO2 increasingly important. Prof. Ben Engel's team at the Biozentrum of the University of Basel together with colleagues from the Universities of ...


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Start-up NextImmune supported by Venture Kick

Development of selective immunosuppressive drugs


NextImmune, a spin-off from the Biozentrum of the University of Basel, has received financial support of 150,000 Swiss francs from the Venture Kick funding initiative. The start-up develops a new generation of immunosuppressive drugs for autoimmune diseases and organ transplantation. The company ...


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The mere sight of a meal triggers an inflammatory response in the brain

Meal stimulates immune defense


Even before carbohydrates reach the bloodstream, the very sight and smell of a meal trigger the release of insulin. For the first time, researchers from the University of Basel and University Hospital Basel have shown that this insulin release depends on a short-term inflammatory response that ...


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