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Neandertal genes in the petri dish

Researchers are studying the Neandertal DNA found in modern humans using stem cells and organoids

22-Jun-2020

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue ...

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Our sleep during lockdown: longer and more regular, but worse

The lockdown has managed to exhaust even good sleepers

16-Jun-2020

A survey conducted at the University of Basel and the Psychiatric Hospital of the University of Basel has investigated how sleep has changed during the Covid-19 lockdown. The 435 individuals surveyed – most of whom were women – reported sleeping longer while sleep quality deteriorated. Research ...

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Protective shield: How pathogens withstand acidic environments in the body

Cell wall as a therapeutic target for the treatment of dangerous MRSA infections

07-May-2020

Certain bacteria, including the dangerous nosocomial pathogen MRSA, can protect themselves from acidic conditions in our body and thus ensure their survival. Researchers at the Biozentrum of the University of Basel have now elucidated an important mechanism in this process. A transport protein ...

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Certain immune cells have different jobs depending on the organ

17-Apr-2020

Group 3 innate lymphoid cells are immune cells that function differently depending on the organ: in the intestines, they prevent certain immune responses, whereas in the spleen they stimulate them. Researchers from the University of Basel have discovered how signals from the surrounding tissue ...

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Virtual screening for active substances against the coronavirus

11-Mar-2020

The University of Basel is part of the global search for a drug to fight the rampant coronavirus. Researchers in the Computational Pharmacy group have so far virtually tested almost 700 million substances, targeting a specific site on the virus – with the aim of inhibiting its multiplication. Due ...

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Specialized helper cells contribute to immunological memory

Potential for new approaches to immunization

10-Mar-2020

Helper T cells play an important role in the immune response against pathogens. The role of a particular subset of these immune cells was previously unclear. It’s now been shown that T follicular helper cells live much longer than previously thought and contribute to long-term immunity. Most ...

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Inner “clockwork” sets the time for cell division in bacteria

12-Feb-2020

Researchers at the Biozentrum of the University of Basel have discovered a “clockwork” mechanism that controls cell division in bacteria. In two publications, in “Nature Communications” und “PNAS”, they report how a small signaling molecule starts the “clock”, which informs the cell about the ...

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Kiss and run: How cells sort and recycle their components

30-Jan-2020

What can be reused and what can be disposed of? Cells also face this tricky task. Researchers from the Biozentrum of the University of Basel have now discovered a cellular machine, called FERARI, that sorts out usable proteins for recycling. In Nature Cell Biology, they explain how FERARI works ...

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Nanocontainers introduced into the nucleus of living cells

29-Jan-2020

An interdisciplinary team from the University of Basel has succeeded in creating a direct path for artificial nanocontainers to enter into the nucleus of living cells. To this end, they produced biocompatible polymer vesicles that can pass through the pores that decorate the membrane of the cell ...

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Molecular factories: The combination between nature and chemistry is functional

13-Jan-2020

Researchers at the University of Basel have succeeded in developing molecular factories that mimic nature. To achieve this they loaded artificial organelles inside micrometer-sized natural blisters (vesicles) produced by cells. These molecular factories remain intact even after injection into an ...

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