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Herpes virus decoded using new methods

A comprehensive systems biological analysis of the herpes virus genome has caused some surprises

30-Apr-2020

The genome of the herpes simplex virus 1 was decoded using new methods. Hundreds of previously unknown gene products were found. The virus causes lip herpes, but can also be life-threatening. Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the ...

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New Molecular Probes for Opioid Receptors

26-Mar-2020

It could be an important step forward in the improvement of pain therapy: Thanks to newly developed molecular probes, the behavior of individual opioid receptors can now be studied in detail. Strong painkillers are very important in the management of patients with cancer and heart attack or ...

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Tracking Down False Parkers in Cancer Cells

12-Mar-2020

In squamous cell carcinoma, a protein ensures that unneeded proteins are no longer disposed of. A research team at the University of Würzburg has switched off this protein for the first time. Squamous cell carcinoma is a very unusual type of cancer. They occur in many tissues – for example in ...

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Virus multiplication in 3D

16-Dec-2019

Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level. For viruses to multiply, they usually need the support of the cells they infect. In many ...

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Achilles Heel of Tumour Cells

06-Nov-2019

In almost all cases of colon cancer, a specific gene is mutated – this offers opportunities to develop broadly effective therapeutic approaches. Research teams in Würzburg have taken this a step further. In 90 percent of all cases of colon cancer, the tumour cells have one thing in common: the ...

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News About Drug Delivery

01-Nov-2019

Nanocontainer for drugs can have their pitfalls: If they are too heavily loaded, they will only dissolve poorly. Why this happens is now reported by a Würzburg research group in "Angewandte Chemie". Nanocapsules and other containers can transport drugs through a patient's body directly to the ...

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Tuberculosis: New insights into the pathogen

11-Oct-2019

Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy. Tuberculosis is a highly contagious infectious disease ...

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Spider silk: A malleable protein provides reinforcement

30-Sep-2019

Scientists from the University of Würzburg have discovered that spider silk contains an exceptional protein. It generates high bonding strength by making use of an amino acid scientists have hitherto paid little attention to. The finding could have important implications in many areas. Why are ...

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Cell Division at High Speed

When two proteins work together, this worsens the prognosis for lung cancer patients

20-Jun-2019

In malignant tumours, the cells usually proliferate quickly and uncontrollably. A research team from the Biocenter of Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, has discovered that two important regulators of cell division can interact in this process. If this is the case, ...

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Protein BRCA1 as a Stress Coach

22-Mar-2019

Two proteins work hand in hand to ensure that the tumour cells of neuroblastoma can grow at full speed. In "Nature", a Würzburg research team shows how the proteins can do this. Anyone who has ever studied the molecular basis of breast cancer will probably have heard of the abbreviation BRCA1 – ...

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