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75 Current news of Uni Würzburg

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Optogenetics: Light Regulates an Enzyme

New tool for cell biology: Würzburg researchers have developed a light sensor with an enzyme function that can be switched on and off with different light colours

30-Mar-2021

The unicellular green alga Chlamydomonas reinhardtii has already given research a massive boost: One of its light sensors, channelrhodopsin-2, founded the success of optogenetics about 20 years ago. In this technology, the alga's light sensor is incorporated into cells or small living organisms ...

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First 3D Images of a Giant Molecule

Resolution up to a millionth of a millimeter

26-Mar-2021

Capturing the structure of large molecular complexes with variable shape is an extremely difficult task. Scientists from Würzburg and Montpellier now have been able to do it – thanks to a new approach regarding an important protein machine. SMN or in full Survival Motor Neuron: Professor Utz ...

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Covid-19 vaccination without a shot?

Scientists at the University of Würzburg are working with a pharmaceutical company on a novel approach to oral vaccination against the coronavirus.

26-Mar-2021

If Professor Thomas Rudel and the biopharmaceutical company Aeterna Zentaris GmbH have their way, there might be significant reinforcements in the fight against the global Corona pandemic in the future: a vaccination that is not administered by syringe but in the form of a capsule that can simply ...

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Why remdesivir does not fully stop the coronavirus

15-Jan-2021

Remdesivir is the first drug against Covid-19 to be conditionally approved in Europe and the United States. The drug is designed to suppress the rapid replication of the SARS-CoV-2 virus in human cells by blocking the viral copying machine, called RNA polymerase. Researchers at the Max Planck ...

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How the coronavirus interacts with cells

First global atlas of direct interactions between SARS-CoV-2 RNA and human host cells

06-Jan-2021

Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One ...

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New Salmonella Proteins Discovered

Only one small protein needs to be missing and salmonellae are no longer infectious

17-Dec-2020

Salmonella are bacteria that can cause food poisoning with severe diarrhoea. If they penetrate from the intestine into the blood system, this can lead to sepsis, life-threatening inflammatory reactions in the entire organism. Since salmonellae are also becoming increasingly resistant to ...

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Cell Membranes in Super Resolution

For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes

04-Dec-2020

Expansion microscopy (ExM) enables the imaging of cells and their components with a spatial resolution far below 200 nanometres. For this purpose, the proteins of the sample under investigation are cross-linked into a swellable polymer. Once the interactions between the molecules have been ...

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A New RNA Catalyst From the Lab

On the track of evolution: a catalytically active RNA molecule that specifically attaches methyl groups to other RNAs

30-Oct-2020

Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes. However, other molecules can also perform enzymatic reactions – for example ribonucleic acids, RNAs. These are then called ribozymes. In this field, ...

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Small RNA as a Central Player in Infections

The most important pathogenicity factors of the gastric pathogen Helicobacter pylori are centrally regulated by a small RNA molecule - And this was not the only surprise

16-Oct-2020

More than half of the world's population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases, it can even lead to the development of stomach cancer. Helicobacter pylori uses ...

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A cancer shredder

A new compound for treating cancer: It destroys a protein that triggers its development

01-Oct-2020

The villain in this drama has a pretty name: Aurora – Latin for dawn. In the world of biochemistry, however, Aurora (more precisely: Aurora-A kinase) stands for a protein that causes extensive damage. There, it has been known for a long time that Aurora often causes cancer. It triggers the ...

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