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75 Current news of Uni Würzburgrss
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New tool for cell biology: Würzburg researchers have developed a light sensor with an enzyme function that can be switched on and off with different light colours
The unicellular green alga Chlamydomonas reinhardtii has already given research a massive boost: One of its light sensors, channelrhodopsin-2, founded the success of optogenetics about 20 years ago. In this technology, the alga's light sensor is incorporated into cells or small living organisms ...
Resolution up to a millionth of a millimeter
Capturing the structure of large molecular complexes with variable shape is an extremely difficult task. Scientists from Würzburg and Montpellier now have been able to do it – thanks to a new approach regarding an important protein machine. SMN or in full Survival Motor Neuron: Professor Utz ...
Scientists at the University of Würzburg are working with a pharmaceutical company on a novel approach to oral vaccination against the coronavirus.
If Professor Thomas Rudel and the biopharmaceutical company Aeterna Zentaris GmbH have their way, there might be significant reinforcements in the fight against the global Corona pandemic in the future: a vaccination that is not administered by syringe but in the form of a capsule that can simply ...
Remdesivir is the first drug against Covid-19 to be conditionally approved in Europe and the United States. The drug is designed to suppress the rapid replication of the SARS-CoV-2 virus in human cells by blocking the viral copying machine, called RNA polymerase. Researchers at the Max Planck ...
First global atlas of direct interactions between SARS-CoV-2 RNA and human host cells
Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One ...
Only one small protein needs to be missing and salmonellae are no longer infectious
Salmonella are bacteria that can cause food poisoning with severe diarrhoea. If they penetrate from the intestine into the blood system, this can lead to sepsis, life-threatening inflammatory reactions in the entire organism. Since salmonellae are also becoming increasingly resistant to ...
For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes
Expansion microscopy (ExM) enables the imaging of cells and their components with a spatial resolution far below 200 nanometres. For this purpose, the proteins of the sample under investigation are cross-linked into a swellable polymer. Once the interactions between the molecules have been ...
On the track of evolution: a catalytically active RNA molecule that specifically attaches methyl groups to other RNAs
Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes. However, other molecules can also perform enzymatic reactions – for example ribonucleic acids, RNAs. These are then called ribozymes. In this field, ...
The most important pathogenicity factors of the gastric pathogen Helicobacter pylori are centrally regulated by a small RNA molecule - And this was not the only surprise
More than half of the world's population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases, it can even lead to the development of stomach cancer. Helicobacter pylori uses ...
A new compound for treating cancer: It destroys a protein that triggers its development
The villain in this drama has a pretty name: Aurora – Latin for dawn. In the world of biochemistry, however, Aurora (more precisely: Aurora-A kinase) stands for a protein that causes extensive damage. There, it has been known for a long time that Aurora often causes cancer. It triggers the ...