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23 Current news of Uni Konstanzrss
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New combination of vaccine and immune checkpoint inhibitors as a promising approach to improving the success of cancer treatment
A new cancer vaccine could boost the positive effects of existing immunotherapy drugs, improving the success rate of treatments from 20% to 75% of cases, according to a new study by immunologists from the University of Konstanz. The vaccine, which incorporates a new immunostimulant that is safe ...
Research team succeeds in directly observing the membrane binding of α-synuclein in living cells
The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the "Parkinson protein", as deposition of this protein in brain cells is a hallmark of Parkinson's disease. Despite the high interest of biomedical research in the protein, many questions ...
Attosecond time resolution in a transmission electron microscope by combining it with a continuous-wave laser achieved
Electron microscopes provide deep insight into the smallest details of matter and can reveal, for example, the atomic configuration of materials, the structure of proteins or the shape of virus particles. However, most materials in nature are not static and rather interact, move and reshape all ...
Researchers have identified a new mechanism that pathogens use to colonize mucosal membranes
Specialized pathogens do not only passively stick to the human mucosa. As a research team at the University of Konstanz has now discovered, they also use the gas nitric oxide (NO) to communicate with their host at short distances to reinforce a firm anchoring of the infected cells in the mucosal ...
Insights into the molecular processes involved in the detection of DNA strand breaks
DNA strand breaks can contribute to the development of cancer and the ageing process. Researchers from the Departments of Biology and Chemistry of the University of Konstanz have now been able to observe in real time the molecular processes that take place at DNA strand breaks by means of ...
A protein complex within the cell has been found to play a key role in preventing the toxicity of proteins which build up amyloid plaques and can lead to neurodegenerative disorders such as Alzheimer’s and Huntington’s disease. Researchers from the Universities of Konstanz (Germany), Leeds (UK) ...
Researchers from the University of Konstanz, Bielefeld University and ETH Zurich demonstrate for the first time that the pulsed EPR technique RIDME (relaxation-induced dipolar modulation enhancement) can be used for in-cell distance determination in biomacromolecules. Applied within the cell, ...
New insights into the recent development of the human immune system
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the scientific journal “Current Biology”. Facilitated by public genome data this work provides evidence that genetic alterations in the receptor ...
Novel inducible disease model for Huntington’s disease
With their first ever RNA-based inducible system for switching on genes in the roundworm Caenorhabditis elegans (C. elegans), two researchers from the University of Konstanz have closed a significant gap in the research on and usage of genetic switches. The new approach was developed as part of a ...
Glucogenic lysine degradation found for the first time
In fact, they were looking for a specific enzyme. What they found is something so fundamental that their new findings might well find their way into textbooks. Referred to here is the amino acid lysine, which is an important building block in proteins. In bacteria and many other organisms, lysine ...