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21 Current news of Uni Konstanzrss
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Attosecond time resolution in a transmission electron microscope by combining it with a continuous-wave laser achieved
Electron microscopes provide deep insight into the smallest details of matter and can reveal, for example, the atomic configuration of materials, the structure of proteins or the shape of virus particles. However, most materials in nature are not static and rather interact, move and reshape all ...
Researchers have identified a new mechanism that pathogens use to colonize mucosal membranes
Specialized pathogens do not only passively stick to the human mucosa. As a research team at the University of Konstanz has now discovered, they also use the gas nitric oxide (NO) to communicate with their host at short distances to reinforce a firm anchoring of the infected cells in the mucosal ...
Insights into the molecular processes involved in the detection of DNA strand breaks
DNA strand breaks can contribute to the development of cancer and the ageing process. Researchers from the Departments of Biology and Chemistry of the University of Konstanz have now been able to observe in real time the molecular processes that take place at DNA strand breaks by means of ...
A protein complex within the cell has been found to play a key role in preventing the toxicity of proteins which build up amyloid plaques and can lead to neurodegenerative disorders such as Alzheimer’s and Huntington’s disease. Researchers from the Universities of Konstanz (Germany), Leeds (UK) ...
Researchers from the University of Konstanz, Bielefeld University and ETH Zurich demonstrate for the first time that the pulsed EPR technique RIDME (relaxation-induced dipolar modulation enhancement) can be used for in-cell distance determination in biomacromolecules. Applied within the cell, ...
New insights into the recent development of the human immune system
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the scientific journal “Current Biology”. Facilitated by public genome data this work provides evidence that genetic alterations in the receptor ...
Novel inducible disease model for Huntington’s disease
With their first ever RNA-based inducible system for switching on genes in the roundworm Caenorhabditis elegans (C. elegans), two researchers from the University of Konstanz have closed a significant gap in the research on and usage of genetic switches. The new approach was developed as part of a ...
Glucogenic lysine degradation found for the first time
In fact, they were looking for a specific enzyme. What they found is something so fundamental that their new findings might well find their way into textbooks. Referred to here is the amino acid lysine, which is an important building block in proteins. In bacteria and many other organisms, lysine ...
Fundamental research for a potential cancer therapy
FAT10 is a small protein with a huge effect. Its attachment to a target protein is a signal for its degradation. FAT10 is a marking system for degradation that seems to be inefficient. In contrast to its biological competitor, ubiquitin, which is recycled, FAT10 is degraded along with its target ...
Scientists decipher a biochemical mechanism significant for tumour biology
Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance for the development of cancer and the fight against that disease. Particularly important is the interaction between the tumour-suppressor ...