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Repair instead of renew: damaged powerhouses of cells have their own ‘workshop mode’

Molecular repair pathway for cellular energy production found

08-Apr-2020

If the energy supply of a cell is disturbed by damage, it can protect itself from functional losses and repair itself in a kind of workshop mode. That is the result of a new study conducted by molecular biologist Professor Dr. Aleksandra Trifunovic and Dr. Karolina Szcepanowska as a leading ...

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Scientists discover novel role for self-recycling process in the brain

Proteins classically associated with autophagy regulate the speed of intracellular transport

01-Apr-2020

Scientists from the laboratory of Dr. Natalia Kononenko at the CECAD Center of Excellence in Aging Research at the University of Cologne have found out that autophagy – the process of cellular self-recycling, or waste clearance – is dispensable for the survival of the neurons in mice. The new ...

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Insights into a versatile molecular death switch

The enzyme caspase-8 regulates different modes of cell death

27-Nov-2019

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard healthy and functioning tissues, cells utilize different cell death mechanisms to dispose of ...

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How cold temperature prolongs fertility and lifespan

23-Aug-2019

To delay the aging process of the entire organism at cold temperature, germ stem cells communicate with the rest of the body using the hormone prostaglandin, as David Vilchez and his team discovered. A moderate reduction of body temperature can induce a remarkable increase in lifespan. This ...

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Like a swimming donut

New way of locomotion discovered in single-celled organisms

14-Jun-2019

A research team led by Dr. Sebastian Hess at the University of Cologne discovered that the unicellular microbe Idionectes vortex moves by means of a rotating flagellum. Special about this discovery is the fact that the flagellum bends into a ring and rotates about its internal axis – enabling ...

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How different antibiotics work together

12-Jun-2019

In modern medicine, antibiotics are as important as they are problematic. On the one hand, they are still the only effective treatment option for many diseases; on the other hand, the number of resistant pathogens is on the rise, a situation about which the WHO already raised a serious warning a ...

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Gold makes invisible surfaces visible in CT

New method for displaying previously invisible surface details using computer tomography developed

10-May-2019

Today, the three-dimensional visualization and analysis of biological samples using computer tomography (CT) is a routine procedure. However, in the past it was very difficult to visualize the fine surface details of many organisms. Scientists at the Universities of Cologne and Bonn and the ...

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The smell of food controls cellular recycling and affects life expectancy

21-Feb-2019

The smell of food affects physiology and aging. That is the result of research conducted on the model organism of the roundworm by a research team led by Professor Thorsten Hoppe at the Cluster of Excellence for Aging Research (CECAD). Surprisingly, this relationship is due to a single pair of ...

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System that reduces neurodegeneration in Huntington’s disease

New therapies possible in the long run

27-Jul-2018

The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne’s Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington’s disease. Particularly, they identified a system ...

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How cells change their shape

Function of protein 'smallish' unraveled

25-Jan-2018

During the development of an embryo, every single cell needs to know who it is, where it is, and what it has to do. Important is the polarity of the cell: Where is the top, where is the bottom, where are front and back? Only when the cell is polarized in the right way can it change the shape in ...

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