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Scientists discover new regulators of the aging process

The attachment of the small protein ubiquitin to other proteins regulates numerous biological processes, including signal transduction and metabolism


Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control numerous processes, such as signal transduction and metabolism. Prof. Dr. David Vilchez and his colleagues at the CECAD Cluster of ...


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Model developed to predict the effect of antibody treatment in HIV infection

The dosage of broadly neutralizing antibodies determines the ability for virus replication


A Cologne-based research collaboration has found a way to predict the effect of broadly neutralizing antibodies (bnAbs) on the growth rate of HIV-1. This finding is the result of a research collaboration among scientists from the University of Cologne’s Institute for Biological Physics and the ...


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Stiffness of skin tissue determines renewal capacity

New insights into the causes of aging


An international team of researchers from the Universities of Cologne and Helsinki have discovered that the ability of stem cells to proliferate and renew organs is regulated by the stiffness of the surrounding tissue. This finding may have implications for improving the regeneration of aged ...


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Protein balance in the reproductive system can prevent disease

Protein balance in sex cells influences protein accumulation in other tissues through specific signaling


A recent study shows that a healthy reproductive system can prevent disease-related protein accumulation in distant tissues, such as neurons, and alteration of mitochondria - the power plants of cells. An imbalance of proteins, for example a build-up of damaged proteins in brain cells, can lead ...


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A new model can predict the evolution of antibiotic resistance in bacteria

An international research team has developed a model that predicts growth rates and resistance mechanisms of common bacterial mutants at different drug doses


A team of scientists from the University of Cologne (Germany) and the University of Uppsala (Sweden) has created a model that can describe and predict the evolution of antibiotic resistance in bacteria. Resistance to antibiotics evolves through a variety of mechanisms. A central and still ...


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New, highly precise ‘clock’ can measure biological age

Researchers expect new insights into how the environment, nutrition, and therapies influence the aging process


Using the model organism Caenorhabditis elegans, researchers at the University of Cologne have developed an ‘aging clock’ that reads the biological age of an organism directly from its gene expression, the transcriptome. Bioinformatician David Meyer and geneticist Professor Dr Björn Schumacher, ...


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Research team discovers mechanism that restores cell function after genome damage

How cells can recover their development and longevity after damage by UV: Discovery may enable therapy against premature aging


A research team from Cologne has discovered that a change in the DNA structure – more precisely in the chromatin – plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). The discovery was ...


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Fine-tuning stem cell metabolism prevents hair loss

Research team has shown in mice that Rictor, a protein that helps to regulate the growth, energy, and oxygen consumption of cells, plays a key role in the cellular metabolism and longevity of hair follicle stem cells


A team of researchers from Cologne and Helsinki has discovered a mechanism that prevents hair loss: hair follicle stem cells, essential for hair to regrow, can prolong their life by switching their metabolic state in response to low oxygen concentration in the tissue. The team was led by ...


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How antibiotics interact

Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics


It is usually difficult to predict how well drugs will work when they are combined. Sometimes, two antibiotics increase their effect and inhibit the growth of bacteria more efficiently than expected. In other cases, the combined effect is weaker. Since there are many different ways of combining ...


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Repair instead of renew: damaged powerhouses of cells have their own ‘workshop mode’

Molecular repair pathway for cellular energy production found


If the energy supply of a cell is disturbed by damage, it can protect itself from functional losses and repair itself in a kind of workshop mode. That is the result of a new study conducted by molecular biologist Professor Dr. Aleksandra Trifunovic and Dr. Karolina Szcepanowska as a leading ...


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