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Simulations show how to make gene therapy more effective

22-Apr-2020

Diseases with a genetic cause could, in theory, be treated by supplying a correct version of the faulty gene. However, in practice, delivering new genetic material to human cells is difficult. A promising method for the delivery of such genes involves the use of DNA/lipid complexes (lipoplexes). ...

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Scientists construct energy production unit for a synthetic cell

19-Sep-2019

Scientists at the University of Groningen have constructed synthetic vesicles in which ATP, the main energy carrier in living cells, is produced. The vesicles use the ATP to maintain their volume and their ionic strength homeostasis. This metabolic network will eventually be used in the creation ...

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Small-volume, high-throughput organic synthesis

New method synthesizes and evaluates large number of drug leads

11-Jul-2019

University of Groningen Professor of Drug Design, Alexander Dömling, has devised a method to rapidly synthesize thousands of new molecules and evaluate their properties as potential drugs. In a paper published by Science Advances on 5 July, he shows that this method works well when applied to ...

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Optimized Binding Cavity

Directed evolution of a designer enzyme with an unnatural catalytic amino acid

05-Feb-2019

The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists have now demonstrated that such fine-tuning is also possible for ...

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New method measures single molecules from nanoliter of blood in real time

09-Oct-2018

University of Groningen scientists, led by Associate Professor of Chemical Biology Giovanni Maglia, have designed a nanopore system that is capable of measuring different metabolites simultaneously in a variety of biological fluids, all in a matter of seconds. The electrical output signal is ...

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Heart failure patients with a higher protein intake live longer

29-May-2018

Heart failure patients who consume more protein live longer, according to research presented at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology congress. Elderly adults need to maintain muscle mass for optimal health. However, most lose muscle ...

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Ecology insights improve plant biomass degradation by microorganisms

27-Jun-2017

Microbes are widely used to break down plant biomass into sugars, which can be used as sustainable building blocks for novel biocompounds. Getting the right microbial community for this process is still a matter of trial and error. New insights by University of Groningen microbial ecologist Dr ...

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Study shows how genes affect immunity in response to pathogens

06-Jul-2016

A study that is first in its kind has looked at how far genetic factors control the immune cell response to pathogens in healthy individuals. A team investigated the response of immune cells from 200 healthy volunteers when stimulated with a comprehensive list of pathogens ex vivo (outside the ...

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The anatomy of flower color

12-May-2016

Roses are red, violets are blue. Everybody knows that, but what makes them so? Although plant breeders were aware of some of the genes involved, there was as yet no quantitative study of how pigment turns a flower red, blue or yellow. Casper van der Kooi conducted just such a study, combining ...

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The origins of abiotic species

06-Jan-2016

How can life originate from a lifeless chemical soup? This question has puzzled scientists since Darwin's 'Origin of species'. University of Groningen chemistry professor Sijbren Otto studies 'chemical evolution' to see if self-organization and autocatalysis will provide the answer. His research ...

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