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From gut to space

Candida albicans exploits lack of oxygen to cause disease

18-Jan-2019

Scientists from Umeå university have shown how the yeast Candida albicans can modulate and adapt to low oxygen levels in different body niches to cause infection and to harm the host. Studying adaption to hypoxic or anoxic niches is particularly fruitful, since it helps us to understand the ...

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Membrane vesicles released by bacteria may play different roles during infection

18-Sep-2017

Bacteria release membrane-derived vesicles (MVs), which are small particles that can transport virulence factors to neighbouring bacteria or to the cells of a mammalian host. This special MV-based system for delivering toxic proteins and nucleic acids in a protected manner to the target cells may ...

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Spotting the invisible

Mapping structures and functions of a transient enzyme state

02-Jun-2017

Chemists at Umeå University have succeeded in mapping structures and functions of a transient enzyme state. By modifying the enzyme adenylate kinase, researchers were able to isolate the molecule and study it using the quantitative techniques X-ray crystallography and nuclear magnetic resonance ...

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Frozen chemistry controls bacterial infections

07-Mar-2017

Chemists and molecular biologists have made an unexpected discovery in infection biology. The researchers can now show that two proteins that bind to one another slow down a chemical reaction central to the course of the disease in the bacteria Yersinia pseudotuberculosis. “The discovery paves ...

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A molecular switch to stop inflammation

16-Oct-2015

Our immune system is vital to us and can sometimes overreact causing chronic illnesses, such as for instance rheumatism and allergy. Now, researchers from Umeå University and University of Gothenburg have identified a molecular switch - MYSM1 - that can suppress such an overreaction and avoid ...

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'Invisible' protein structure explains the power of enzymes

07-Jul-2015

A research group at Umeå University in Sweden has managed to capture and describe a protein structure that, until now, has been impossible to study. The discovery lays the base for developing designed enzymes as catalysts to new chemical reactions for instance in biotechnological applications. ...

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Better preparedness against influenza viruses

12-Dec-2013

Researchers in Umeå and Uppsala have found that residues of the influenza drug Tamiflu in our environment can make the influenza virus in birds resistant. This can have serious consequences in the event of an influenza pandemic. With more than 14 million SEK from the Swedish Research Councils ...

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New research findings enable more reliable prognoses for breast cancer

19-May-2008

Researchers at Umeå University in Sweden have shown that the length of telomeres in blood cells in newly diagnosed breast cancer patients is tied to survival rates. The study was carried out by a research team headed by Professor Göran Roos at the Department of Medical Bioscience, Pathology. The ...

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