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Cancer: Inactive receptor renders immunotherapies ineffective

Important reason for poor response to checkpoint inhibitors identified

16-Oct-2019

The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team ...

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ClpX-ClpP protein complex could be starting point for new antibiotics

Weak spot in pathogenic bacteria

08-Oct-2019

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key ...

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The secret of motivation

How neural circuits drive hungry individuals to peak performance

30-Sep-2019

Success is no accident: To reach your goal you need perseverance. But where does the motivation come from? An international team of researchers led by scientists from the Technical University of Munich (TUM) has now identified the neural circuit in the brain of fruit flies which makes them ...

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Chaperones detect immature signaling molecules in the immune system

Quality control in immune communication

25-Sep-2019

The cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team led by researchers from the Technical University of Munich (TUM) has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune ...

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“Genetic variants associated with educational attainment” can also have positive implications for lifestyle

Major population study investigates the interplay between genetics, educational attainment and cardiovascular disease

20-Sep-2019

A German and British research team lead by the Technical University of Munich (TUM) has examined the interplay between genetics, cardiovascular disease and educational attainment in a major population study. Genetic variants which had been linked to educational attainment in other studies were ...

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Cause of early cellular dysfunction in Alzheimer’s disease recognized for the first time

Direct toxic action of beta-amyloid identified

13-Aug-2019

Hyperactive neurons in specific areas of the brain are believed to be an early perturbation in Alzheimer's disease. For the first time, a team from the Technical University of Munich (TUM) was able to explain the reasons and mechanisms underlying this early and therefore important neuronal ...

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The Art of Sensing within the Skin

Dermal tattoo sensors for the detection of blood pH change and metabolite levels

22-Jul-2019

The art of tattooing may have found a diagnostic twist. A team of scientists in Germany have developed permanent dermal sensors that can be applied as artistic tattoos. As detailed in the journal Angewandte Chemie, a colorimetric analytic formulation was injected into the skin instead of tattoo ...

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The physiology of survival

For bacteria, the neighbors co-determine which cell dies first

19-Jul-2019

Bacteria do not simply perish in hunger phases fortuitously; rather, the surrounding cells have a say as well. A research team from the Technical University of Munich (TUM) has now discovered that two factors, above all, decide over life and death: the energy required to continue living and the ...

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Successful T cell engineering with gene scissors

CRISPR/Cas9-modified T cells could solve immunotherapy problems

15-Jul-2019

The idea of genetically modifying a patient’s own immune cells and deploying them against infections and tumors has been around since the 1980s. But to this day modified T cells are still not as effective as natural T cells and have been only been of limited clinical value. Using the new ...

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Artificial DNA can control release of active ingredients from drugs

02-Jul-2019

A drug with three active ingredients that are released in sequence at specific times: Thanks to the work of a team at the Technical University of Munich (TUM), what was once a pharmacologist's dream is now much closer to reality. With a combination of hydrogels and artificial DNA, nanoparticles ...

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