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Cause found for higher sex-specific risk of mortality

A protein causes higher sex-specific risk of severe cancer progression for men

07-Oct-2021

A remarkable number of life-threatening diseases manifest more severely in males than in females. One current example is COVID-19 caused by SARS CoV-2. Another example is the significantly higher risk of severe cancer progression for men. A research team at the Technical University of Munich ...

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Machine learning assisted structure analysis reveals SARS-CoV-2 virus tactics

The proteins of Covid-19

17-Sep-2021

The proteins of SARS-CoV-2 play key roles in how the virus manages to evade immune defense and replicate itself in patients’ cells. An international research team – with significant contribution from the Technical University of Munich (TUM) – has now compiled the most detailed view of the virus' ...

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Messengers from gut to brain

Seen for the first time: T cells traveling from the gut and skin to the central nervous system

09-Sep-2021

Scientists have long been aware of a link between the gut microbiome and the central nervous system (CNS). Until now, however, the immune cells that move from the gut into the CNS and thus the brain had not been identified. A team of researchers in Munich has now succeeded in using violet light ...

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New approach identifies T cells in Covid-19 patients

Immune cell profile reveals appearance, number and activity level against SARS-CoV-2

20-Aug-2021

T cells play a decisive role in fighting the coronavirus and preventing infected individuals from becoming seriously ill. They identify and fight the virus directly within the infected cells. A team of researchers working in Munich have produced a precise profile of the T cells that respond to ...

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Taking aim at skin bacteria

Enzyme treatment of skin samples improves microbiome analysis

13-Aug-2021

Healthy skin has a bacterial shield to protect against germs: the microbiome. This complex assembly of microorganisms was previously believed to be difficult to decipher. A team of researchers has now succeeded in using the enzyme benzonase to identify the living bacteria in skin swabs through ...

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The virus trap

Hollow nano-objects made of DNA could trap viruses and render them harmless

16-Jul-2021

To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami ...

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Versatile and reliable SARS-CoV-2 antibody assay

Automated microarray rapid test for detecting SARS-CoV-2 antibodies

28-Jun-2021

During the continued progression of the Corona pandemic, rapid, inexpensive, and reliable tests will become increasingly important to determine whether people have the associated antibodies – either through infection or vaccination. Researchers at the Technical University of Munich (TUM) have now ...

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How satiation can be controlled

Secretin hormone induces satiation by activating brown fat

24-Jun-2021

Researchers at the Technical University of Munich (TUM) and the Finnish research institute Turku PET Centre have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue. Brown adipose ...

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The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression

07-Jun-2021

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...

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"Corona fuels a different pandemic"

Survey on diet and exercise since the start of the corona pandemic presented

03-Jun-2021

How has the corona pandemic affected the dietary and exercise behavior and thus the weight of adults? Researchers at the Technical University of Munich (TUM) have investigated this question and found that about 40 percent of those surveyed have gained weight since the start of the pandemic and ...

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