Systematic depiction of previously unknown gene functions

Largest cellular proteomic study of yeast cells unlocks fundamental insights

03-May-2023 - A proteome is the entirety of all active protein molecules present within an organism, a certain type of tissue, or a cell under specific conditions and at a certain time. Now, an international team of researchers led by members from Charité – Universitätsmedizin Berlin, the Francis Crick ...

Fungal infections: Microbial cooperation leads to drug tolerance

Fungal infections represent an increasingly significant health issue and are more dangerous than previously thought

28-Mar-2022 - The treatment of fungal infections is often hampered by fungal pathogens that do not respond, or are tolerant, against anti-fungal drugs. A team of researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have now identified microbial cooperation as one of the causes ...

Could the blood of COVID-19 patients be used to predict disease progression?

Study discovers differences in the blood samples of severe and mild cases

09-Jun-2020 - Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have identified 27 proteins which are present at different levels in the blood of COVID-19 patients, depending on the severity of their symptoms. These biomarker profiles could be used to predict disease ...

Stem cells in human embryos commit to specialization surprisingly early

The point when human embryonic stem cells irreversibly commit to becoming specialised has been identified by researchers at the Francis Crick Institute

22-Apr-2020 - Our biological history can be traced back to a small group of cells called embryonic stem cells, which through cell division, give rise to cells that specialise to perform a specific role in the body - a process known as differentiation. Understanding when and how embryonic stem cells specialise ...

Molecular 'magnets' could improve cancer immunotherapy

12-Feb-2018 - Chemicals that attract specialised immune cells toward tumours could be used to develop better immunotherapies for cancer patients, according to new research. Scientists at the Francis Crick Institute have discovered that immune cells called Natural Killer cells accumulate in tumours and release ...

Chemo-boosting drug discovered for leukemia

04-Sep-2017 - Drugs developed to treat heart and blood vessel problems could be used in combination with chemotherapy to treat an aggressive form of adult leukemia, new research led by the Francis Crick Institute reveals. In a study published in Cancer Cell, researchers at the Francis Crick Institute, King's ...

Understanding the architecture of our 'second brain'

22-May-2017 - Scientists have made an important step in understanding the organisation of nerve cells embedded within the gut that control its function -- a discovery that could give insight into the origin of common gastrointestinal diseases, including irritable bowel syndrome and chronic constipation. The ...

Science begins in the new Francis Crick Institute building

01-Aug-2016 - The first scientists have moved into the new £650 million Francis Crick Institute building in London and are starting work in their purpose-built labs. Next to St Pancras station and the British Library, the Crick will be the biggest biomedical research institute under one roof in ...