Specific brain responses to traumatic stress linked to PTSD risk

A new study shows how decreased hippocampus engagement is associated with the development of posttraumatic stress disorder

29-Jul-2022 - Results from the largest prospective study of its kind indicate that in the initial days and weeks after experiencing trauma, individuals facing potentially threatening situations who had less activity in their hippocampus – a brain structure critical for forming memories of situations that are ...

HIV eliminated from the genomes of living animals

03-Jul-2019 - In a major collaborative effort, researchers at the Lewis Katz School of Medicine at Temple University and the University of Nebraska Medical Center (UNMC) have for the first time eliminated replication-competent HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals. The ...

Key factor in mitochondrial calcium uptake and bioenergetics identified

17-May-2016 - Mitochondria are the energy-generating batteries of cells, but they also perform other critical functions, including protecting cells against calcium overload, a significant cause of cell death in certain cardiovascular and neurodegenerative diseases. Underlying this safety mechanism is a protein ...

Small molecule inhibitor shows promise in precision cancer targeting

09-Nov-2015 - Cancer cells with mutations in BRCA1 or BRCA2 genes, which serve a vital role in preserving the integrity of the genetic code, are key targets for cancer therapeutics. Yet, few agents can selectively eliminate cells deficient in BRCA, and none can do so without the risk of inducing drug ...

Blinded by genetic mutation

Team characterizes genetic mutations linked to a form of blindness

05-Oct-2015 - Achromatopsia is a rare, inherited vision disorder that affects the eye's cone cells, resulting in problems with daytime vision, clarity and color perception. It often strikes people early in life, and currently there is no cure for the condition. One of the most promising avenues for developing ...

Temple scientists target DNA repair to eradicate leukemia stem cells

12-Dec-2012 - Despite treatment with imatinib, a drug that targets chronic myeloid leukemia (CML, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression ...

GVK Biosciences announces multi-year drug discovery collaboration with the Moulder Center for Drug Discovery Research, Temple University

30-Nov-2011 - GVK Biosciences announced today that it has entered into a drug discovery alliance with the Moulder Center for Drug Discovery Research at Temple University. As part of the multi-year integrated drug discovery collaboration, GVK BIO will be responsible for the target validation, lead ...

Marijuana component could ease pain from chemotherapy drugs

10-Oct-2011 - A chemical component of the marijuana plant could prevent the onset of pain associated with drugs used in chemo therapy, particularly in breast cancer patients, according to researchers at Temple University's School of Pharmacy.The researchers published their findings, "Cannabidiol Prevents the ...