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9 Current news of Rudolf-Virchow-Zentrum/ DFG-Forschungszentrum für Experimentelle Biomedizin der Universität Würzburg

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Bacteria under stress

Understand bacterial defense mechanisms in detail

09-Nov-2020

In stress situations, bacteria use special ion channels for defense. Understanding how they function provides the basis for combating harmful bacteria. A Würzburg research group in cooperation with ETH Zurich and the University of Oxford has now been able to decipher how two of these channels are ...

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It’s all about the right balance

New findings provide a structural framework for the development of new cancer-therapeutic strategies

28-Oct-2020

Collaborative work of research groups at the University of Würzburg and the TU Dresden has provided important new insights for cancer research. During cell division specific target proteins have to be turned over in a precisely regulated manner. To this end specialized enzymes label the target ...

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Puzzle solved after 16 years

Exact functionality of the protein complex CDK-activating kinase (CAK) resolved

20-Oct-2020

A research group from Würzburg has now been able to clarify the long-standing question of how the protein complex CDK-activating kinase (CAK), which controls the central processes of cell division and transcription, is activated. The group analyzed the active form of the protein/CAK complex and ...

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Specific control molecule in platelets identified

Starting point for drug development against thrombosis, heart attack and stroke

12-Aug-2020

The previously largely unknown molecule bridging integrator 2 (BIN2) plays a central role in platelet activation, as researchers from Würzburg have now shown in a joint project of the DFG Collaborative Research Centre/Transregio 240. This finding provides indications of starting points for drug ...

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Touchable corona viruses

Research group prints the first biologically correct 3D model of the SARS-CoV-2 virus

04-Aug-2020

Viruses are tiny. They cannot be seen with the naked eye and they are even too small for optical microscopes, which makes it difficult to recognize the danger that COVID-19 and its pathogen SARS-CoV-2 pose to the world. This is why the international Coronavirus Structural Task Force led by Dr. ...

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Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow

17-Jul-2019

Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The ...

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Substantial differences between the tumor-promoting enzymes USP25 and USP28 identified

A new guide for cancer drugs

28-Mar-2019

Researchers from the Rudolf Virchow Center of the University of Würzburg (JMU) have solved the structures of the cancer-promoting enzymes USP25 and USP28 and identified significant differences in their activities. Both enzymes promote the growth of various tumors. The results were published in ...

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Cellular waste management

How animal cells protect themselves against dangerous goods

22-Mar-2017

In two recent papers, scientists Ahmad Fazeli and Ann Wehman from the University of Würzburg have published new insights into waste disposal in animal cells. These findings may help to better understand the molecular mechanisms underlying autoimmune diseases like lupus. Animal cells have ...

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Researchers identified an important signaling molecule of cell communication

30-Mar-2016

International scientists led by Carsten Hoffmann and Martin Lohse of the University Würzburg, Germany, identified for the first timeβ-Arrestin as an independent signaling molecule. The protein modulates a pharmaceutically important pathway. It leads to new drug targets, for example in pain ...

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