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16 Current news of Osaka University

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Biomarker helps identify 'window of opportunity' for cancer chemotherapy timing

11-Apr-2018

Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics. Combination therapy using angiogenesis ...

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Growing organs a few ink drops at a time

03-Jan-2018

Printed replacement human body parts might seem like science fiction, but this technology is rapidly becoming a reality with the potential to greatly contribute to regenerative medicine. Before any real applications, "bioprinting" still faces many technical challenges. Processing the bio-ink and ...

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A new twist on asymmetric catalysis

28-Sep-2017

In the same way a glove will only fit one hand, molecules have the symmetry that controls their behavior and interactions. In drug design, this means reversing the symmetry of a molecule can mean the difference between an effective treatment or a compound that has serious negative effects. As a ...

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The fork in the road to DNA repair

13-Jul-2017

The human body consists of trillions of cells, and within each are billions of DNA molecules. Strict maintenance of the molecules is essential to maintain a healthy cell and thus a healthy body. This maintenance is challenged by the daily bombardment of chemicals, UV light, radical oxgen and ...

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How different drugs interact with the same target

18-May-2017

Tumor necrosis factor (TNF) is involved in a range of inflammatory diseases including rheumatoid and psoriatic arthritis, ankylosing spondylitis, and psoriasis. Several drugs that target TNF are available to treat these conditions; however, despite acting on the same target, their clinical ...

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Computer simulation of protein synthesis reveals high complexity of cell machinery

20-Mar-2017

Life depends on proteins. These molecules are produced continually in our cells, which act as microscopic production lines - but the process is so complex we have barely begun to understand it. Exploring protein synthesis may, however, be the key to revealing how the body controls the thousands ...

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Role of protein in pancreatic secretion suggests potential method for treating diabetes

12-Dec-2016

Research reveals opposing roles for SNAP23 protein in the enzyme- and hormone-secretion functions of the pancreas; SNAP23 inhibitor increased insulin secretion in mice, suggesting potential use as a novel therapy for diabetes Osaka, Japan - Movement of secretory molecules, such as hormones and ...

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Behavior of sugar transport proteins visualized

18-Nov-2016

A group of researchers led by Kazuya Kikuchi, professor at the Graduate School of Engineering, Osaka University, clarified the role of a N-glycan chain on glucose transporter type 4 (GLUT4) by developing a method for visualizing intracellular trafficking of proteins. The GLUT4 translocation ...

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May repairs full of mistakes develop into cancer?

25-May-2016

A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor ...

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New method for exhaustively isolating olfactory receptors responding to specific odorants

29-Apr-2016

A research group led by Osaka University and Panasonic Corporation developed a method for making a prompt, exhaustive isolation of olfactory receptors (ORs) responding to the odorant of interest. This achievement will enable quick and easy exhaustive analysis of ORs responding to specific ...

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