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New protein neutralizes COVID in tiny human kidney

Modified ACE2 tricks virus into binding with it instead of real cell

03-Feb-2021

Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab. The protein is a variant of ACE2 (angiotensin converting enzyme-2), the receptor the ...

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Research exposes new vulnerability for SARS-CoV-2

Electrostatic interactions enhance the spike protein's bond to host cells

13-Aug-2020

Northwestern University researchers have uncovered a new vulnerability in the novel coronavirus' infamous spike protein -- illuminating a relatively simple, potential treatment pathway. The spike protein contains the virus' binding site, which adheres to host cells and enables the virus to enter ...

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Many of the deadliest cancers receive the least amount of research funding

'Embarrassing' or stigmatized cancers like lung and liver are underfunded

23-Jul-2019

Many of the deadliest or most common cancers get the least amount of nonprofit research funding, according to a new Northwestern Medicine study that examined the distribution of nonprofit research funding in 2015 across cancer types. Colon, endometrial, liver and bile duct, cervical, ovarian, ...

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'Trojan horse' anticancer drug disguises itself as fat

Promising system delivers chemo drug straight into tumors with fewer side effects

19-Jul-2019

A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth. The drug also is lower in ...

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Methane-consuming bacteria could be the future of fuel

Discovery illuminates how bacteria turn methane gas into liquid methanol

13-May-2019

Known for their ability to remove methane from the environment and convert it into a usable fuel, methanotrophic bacteria have long fascinated researchers. But how, exactly, these bacteria naturally perform such a complex reaction has been a mystery. Now an interdisciplinary team at Northwestern ...

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Night owls have higher risk of dying sooner

13-Apr-2018

"Night owls" - people who like to stay up late and have trouble dragging themselves out of bed in the morning - have a higher risk of dying sooner than "larks," people who have a natural preference for going to bed early and rise with the sun, according to a new study from Northwestern Medicine ...

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Bacteria eats greenhouse gas with a side of protein

26-Mar-2018

With the ability to leech heavy metals from the environment and digest a potent greenhouse gas, methanotrophic bacteria pull double duty when it comes to cleaning up the environment. But before researchers can explore potential conservation applications, they first must better understand the ...

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Using DNA, nanoparticles and lithography to make optically active structures

22-Jan-2018

Northwestern University researchers have developed a first-of-its-kind technique for creating entirely new classes of optical materials and devices that could lead to light bending and cloaking devices -- news to make the ears of Star Trek's Spock perk up. Using DNA as a key tool, the ...

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New imaging technique peers inside living cells

20-Nov-2017

To undergo high-resolution imaging, cells often must be sliced and diced, dehydrated, painted with toxic stains, or embedded in resin. For cells, the result is certain death. But if researchers can only view the inner workings of dead cells, they're only seeing part of the story. They cannot ...

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Scientists capture colliding organic nanoparticles on video for first time

20-Nov-2017

A Northwestern University research team is the first to capture on video organic nanoparticles colliding and fusing together. This unprecedented view of "chemistry in motion" will aid Northwestern nanoscientists developing new drug delivery methods as well as demonstrate to researchers around the ...

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