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32 Current news of MPI für molekulare Zellbiologie und Genetik


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Measuring Organ Development

Metrics for organ development have now been defined for the first time


Researchers from Dresden and Vienna reveal link between connectivity of three-dimensional structures in tissues and the emergence of their architecture to help scientists engineer self-organising tissues that mimic human organs. Organs in the human body have complex networks of fluid-filled tubes ...


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2023 Breakthrough Prize in Life Sciences for Anthony Hyman and Clifford Brangwynne

World’s largest science prize for discovering a new mechanism of cellular organization


Anthony Hyman, the managing director of the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), and Clifford Brangwynne, Professor of Chemical and Biological Engineering at Princeton University and Howard Hughes Medical Institute, have been honored with one of the three 2023 ...


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Structures considered key to gene expression are surprisingly fleeting

Study finds genome loops don’t last long in cells; theories of how loops control gene expression may need to be revised


In human chromosomes, DNA is coated by proteins to form an exceedingly long beaded string. This “string” is folded into numerous loops, which are believed to help cells control gene expression and facilitate DNA repair, among other functions. A new study from the Massachusetts Institute of ...


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Catch me if you can: how mRNA therapeutics are delivered into cells

Novel insights into the development of RNA therapeutics towards efficient delivery and lower dosages


Researchers have found where and how mRNA arrives in a cell to modify or deliver genetic information, a crucial process for the development of novel therapies. In recent years, ribonucleic acid (RNA) has emerged as a powerful tool for the development of novel therapies. RNA is used to copy ...


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Researchers uncover microstructural elements in liver cells that might aid early detection of disease


The liver is our largest metabolic organ vital for detoxification and digestion. The liver produces bile, a digestive fluid that is drained into the intestine. To transport bile, liver cells form a network of tiny tubules (bile canaliculi) essential for organ function. Researchers at the Max ...


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Human-specific gene makes mice smarter

A gene, found only in humans, leads to a larger brain, increased memory flexibility and reduced anxiety in mice


During human evolution, the neocortex, the evolutionarily youngest part of the cerebral cortex, expanded dramatically and made the human brain larger. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden had shown in previous studies that in the ...


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A new era of genome sequencing

16 new high-quality reference genomes from vertebrates


The international Vertebrate Genomes Project (VGP) publishes their flagship study focused on genome assembly quality and standardization for the field of genomics in a special issue of Nature, along with 20 associated publications. This study presents 16 diploid high-quality, near error-free, and ...


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Keeping Sperm Cells on Track

Researchers point to a new mechanism underlying male infertility


One essential component of each eukaryotic cell is the cytoskeleton. Microtubules, tiny tubes consisting of a protein called tubulin, are part of this skeleton of cells. Cilia and flagella, which are antenna-like structures that protrude from most of the cells in our body, contain many ...


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The genetic basis of bats’ superpowers revealed

First six reference-quality bat genomes released and analysed


For the first time, the raw genetic material that codes for bats’ unique adaptations and superpowers such as the ability to fly, to use sound to move effortlessly in complete darkness, to survive and tolerate deadly diseases, to resist ageing and cancer - has been fully revealed. Bat1K, a global ...


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The lipid code

New chemical tools can control the concentration of lipids in living cells


Lipids, or fats, have many functions in our body: They form membrane barriers, store energy or act as messengers, which regulate cell growth and hormone release. Many of them are also biomarkers for severe diseases. So far, it has been very difficult to analyze the functions of these molecules in ...


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