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Embryonic development in a Petri dish

3D cell culturing technique could replace mouse embryos

14-Dec-2020

By growing mouse stem cells in a special gel, a Berlin research team succeeded to grow structures similar to parts of an embryo. The trunk-like structures develop the precursors for neural, bone, cartilage and muscle tissues from cellular clumps within five days. This could allow the ...

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Scaffold of sub-cellular structures identified after a hundred years

Getting to the core of nuclear speckles

01-Dec-2020

Nuclear speckles are tiny agglomerations of proteins in the nucleus of the cell that are involved in the processing of genetic information. Berlin researchers have now discovered how nuclear speckles are constructed and were able to close a long-standing gap in research. When the famous Spanish ...

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Breaks in the genome

New method to improve the diagnosis of genetic diseases

28-Jul-2020

Breaks and rearrangements in the genome can lead to severe diseases, even if all genes remain intact. Hi-C, a method to map the three-dimensional structure of chromosomes, promises more reliable and accurate diagnoses of such defects, but is not used in the clinic yet. A team of researchers at ...

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Unexpectedly potent protein droplets

Researchers discover new pathomechanism of hereditary diseases in cell condensates

11-May-2020

Repeats of individual building blocks within proteins are the cause of many hereditary diseases, but how such repeats actually cause disease is still largely unknown. Researchers in Berlin investigated how repeat elongations lead to the disease synpolydactyly, and have found that the attractive ...

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Swiss Army Knife for Genome Research

Multifunctional tool CRUP makes enhancer prediction quick and easy

21-Nov-2019

It is the the dream of every molecular geneticist: an easy-to-use program that compares data sets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. A research team led by Professor Martin Vingron at the Max Planck Institute for Molecular ...

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A molecular switch for the X chromosome

Elucidation of basic mechanism to initiate the inactivation of X chromosomes in female organisms

10-Apr-2019

A large number of genes have to be switched on or off at different times during development. A particular challenge occurs when two copies of the same gene must acquire opposing states of activation within the same cell, as it is the case, for example, for the two X chromosomes in the female ...

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Decoding Lil BUB: Crowdfunded project reveals genome of internet celebrity cat

06-Mar-2019

Lil BUB has drawn millions of followers across the internet for her cute appearance. Behind the celebrity cat’s unique features is a combination of two rare genetic variants, three molecular biologists from Germany and the US report. The results of their crowdfunded project “LilBUBome” are now ...

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Relationships inside a cell

Scientists publish the first RNA interactome of the human nucleus

06-Apr-2016

Studying sequence and function of DNA has been in the focus of life sciences for decades, but now the interest of many researchers has turned to the RNA. Today, many scientists believe that RNA molecules, together with a variety of different proteins, play a regulatory or structural role in ...

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New diagnostic method identifies genetic diseases

PhenIX can identify genetic diseases quickly and reliably based on analyses of genes and symptoms

19-Sep-2014

People with genetic diseases often have to embark on an odyssey from one doctor to the next. Fewer than half of all patients who are suspected of having a genetic disease actually receive a satisfactory diagnosis. Scientists from the Charité - Universitätsmedizin Berlin and the Max Planck ...

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Epigenetic control of cardiogenesis

Non-coding RNA is essential for normal embryonic cardiogenesis

01-Feb-2013

Many different tissues and organs form from pluripotent stem cells during embryonic development. To date it had been known that these processes are controlled by transcription factors for specific tissues. Scientists from the Max Planck Institute for Molecular Genetics in Berlin, in collaboration ...

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