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Tracking titin in real time

17-Dec-2019

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body’s largest protein, in real time throughout its entire lifecycle. The method and results could provide new insight into muscle development as well as treating damaged muscles and heart ...

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What blocks bird flu in human cells?

12-Dec-2019

Normally, bird flu viruses do not spread easily from person to person. But if this does happen, it could trigger a pandemic. Researchers from the MDC and RKI have now explained in the journal Nature Communications what makes the leap from animals to humans less likely. Whenever people suddenly ...

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Deep learning identifies molecular patterns of cancer

04-Dec-2019

An artificial intelligence platform developed at the Max Delbrück Center for Molecular Medicine (MDC) can analyze genomic data extremely quickly, picking out key patterns to classify different types of colorectal tumors and improve the drug discovery process. The deeper analysis shows some ...

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3D maps of gene activity

22-Nov-2019

A three-dimensional computer model enables scientists to quickly determine which genes are active in which cells, and their precise location within an organ. A team led by Nikolaus Rajewsky, Berlin, and Nir Friedman, Jerusalem, has published the new method and their insights gained from this in ...

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FLAM-seq: the full picture of messenger RNA and their tails

19-Aug-2019

Researchers in MDC’sBerlin Institute for Medical Systems Biology(BIMSB)have developed atoolenablingaccurate sequencing ofmessenger RNA along withtheirtails for the first time.ProfessorNikolausRajewskyand his team described this new tool, called full-length poly(A) and mRNA ...

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A genetic chaperone for healthy aging?

14-Aug-2019

Researchers at the Max Delbrück Center for Molecular Medicine (MDC) have identified an epigenetic mechanism that appears to strongly influence healthy aging. It’s a protein that controls muscle integrity, lifespan and levels of an essential sugar. How does one protein have that much ...

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Google Maps for tissues

08-Aug-2019

Modern light microscopic techniques provide extremely detailed insights into organs, but the terabytes of data they produce are usually nearly impossible to process. New software, developed by a team led by MDC scientist Dr. Stephan Preibisch and now presented in Nature Methods, is helping ...

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Keeping a cell’s powerhouse in shape

12-Jul-2019

A German-Swiss team around Professor Oliver Daumke from the MDC has investigated how a protein of the dynamin family deforms the inner mitochondrial membrane. Mitochondria are the powerhouses of our cells, generating energy in the form of chemical compounds such as ATP. To do this job ...

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Decoding Lil BUB: Crowdfunded project reveals genome of internet celebrity cat

06-Mar-2019

Lil BUB has drawn millions of followers across the internet for her cute appearance. Behind the celebrity cat’s unique features is a combination of two rare genetic variants, three molecular biologists from Germany and the US report. The results of their crowdfunded project “LilBUBome” are now ...

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How dietary fiber and gut bacteria protect the cardiovascular system

17-Dec-2018

he fatty acid propionate helps defend against the effects of high blood pressure, including atherosclerosis and heart tissue remodeling, a study on mice has found. Gut bacteria produce the substance – which calms the immune cells that drive up blood pressure – from natural dietary fiber. “You are ...

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