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How ApoE4 endangers the brain

A potential new approach to Alzheimer’s therapeutics?

06-Jul-2020

Apolipoprotein E4 is considered the most important genetic risk factor for Alzheimer’s disease. A group of researchers, led by MDC scientist Thomas Willnow, has now discovered how ApoE4 can damage the brain. Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It ...

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Fantastic muscle proteins and where to find them

“This is going to be unexpected even for myosin researchers”

24-Jun-2020

Setting out to identify all proteins that make up the sarcomere, the basic contractile unit of muscle cells, resulted in an unexpected revelation, providing experimental evidence that helps explain a fundamental mystery about how muscles work. The research was published in Nature ...

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Overactive enzyme causes hereditary hypertension

Hope for new and more effective therapeutic approaches for hypertension

19-Jun-2020

After more than 40 years, several teams at the MDC and ECRC have now made a breakthrough discovery with the help of two animal models: they have proven that an altered gene encoding the enzyme PDE3A causes an inherited form of high blood pressure. This could lead to new concepts for the treatment ...

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Likely Entrypoints for SARS-CoV-2

Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus

24-Apr-2020

Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells. The identification of these cells by researchers from the Wellcome Sanger Institute, University Medical Centre ...

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Diagnostics, meet CRISPR

15-Apr-2020

A new diagnostic test to quickly and easily monitor kidney transplant patients for infection and rejection relies on a simple urine sample and a powerful partner: the gene-editing technology CRISPR. Michael Kaminski, who developed it, leads a new Emmy Noether Group at the MDC & Charité. The ...

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Protein controls fat metabolism

18-Mar-2020

A protein in the cell envelope influences the rate of fatty acid uptake in cells. This is reported by MDC researchers in the journal PNAS. This process also appears to be altered in overweight people. Many foods – whether it’s the mozzarella on your favorite pizza, the olive oil in salad dressing ...

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On the trail of cancer stem cells

What goes on inside and between individual cells during the very earliest stages of tumor development?

24-Feb-2020

Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells. Two research teams from the Max Delbrück Center for Molecular Medicine and their collaborators have ...

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Cutting off kidney cancer at its roots

19-Feb-2020

Scientists at the MDC have discovered stem cells responsible for the most common form of kidney cancer. The team of Walter Birchmeier has found a way to block the growth of these tumors in three models of the disease. Not all cancer cells are equal. Tumors contain potent cancer stem cells which ...

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Harnessing jumping genes to advance gene-therapy cancer treatment

PlasmidFactory partnership to continue

21-Jan-2020

In an effort to optimize the Sleeping Beauty system, the MDCell – Helmholtz Innovation Lab is extending its collaboration with PlasmidFactory. If you want to modify a human body’s immune cells – for example by giving them new vitality to fight a tumor or stop an autoimmune disease – you need safe ...

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Tracking titin in real time

17-Dec-2019

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body’s largest protein, in real time throughout its entire lifecycle. The method and results could provide new insight into muscle development as well as treating damaged muscles and heart ...

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