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Chronobiology: Sleep and synaptic rhythms

15-Oct-2019

Chronobiologists at Ludwig-Maximilians-Universität (LMU) in Munich, Germany, show in two articles in the journal Science how critical the sleep-wake cycle is for protein and phosphorylation dynamics in synapses to ultimately regulate its activity. The internal clock controls virtually all ...

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Parasitology: Mother cells as organelle donors

17-Sep-2019

Microbiologists at LMU and UoG have discovered a recycling process in the eukaryotic parasite Toxoplasma gondii that plays a vital role in the organism’s unusual mode of reproduction. Toxoplasma gondii, the unicellular causative agent of toxoplasmosis, reproduces itself in an unusual fashion by ...

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Cancer research: The genetic context is crucial

16-Sep-2019

An LMU team has uncovered a mechanism behind the variability in the clinical course of Ewing sarcoma. The interaction between the acquired driver mutation and the germline genetic context in which it occurs determines the course of the disease. Dr. Thomas Grünewald studies the genetics and ...

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DNA repair: Opening the hatch to heal the break

05-Sep-2019

LMU researchers have determined the structure of a key enzyme complex that is involved in DNA repair, and traced the cycle of conformational changes that it undergoes while performing its biochemical function. Various types of DNA damage can have serious repercussions, both for the individual ...

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Alzheimer’s disease: Protective immune response in the brain?

02-Sep-2019

LMU researchers Christian Haass and Michael Ewers have identified a factor that might possibly delay the emergence and slow the progression of Alzheimer’s disease. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the Institute for Stroke and Dementia Research (ISD) at ...

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Bringing cancer medication safely to its destination

12-Aug-2019

Treating cancer more selectively and more effectively – this could be achieved with an innovative technology developed by teams of researchers at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Ludwig-Maximilians-Universität München (LMU). The process transforms proteins ...

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Tiny “blinkers” reveal molecules inside cells

18-Mar-2019

LMU physicists led by Ralf Jungmann introduce an entirely new approach to super-resolution microscopy: Tiny ‘blinkers’ enable simultaneous imaging of multiple biomolecules. In everyday life, blinking lights can send signals – for example, that a car is going to turn. Now, researchers have ...

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Defective immune cells in the brain cause Alzheimer’s disease

Scientists are studying the role of immune cell activation in Alzheimer's disease

09-Jan-2019

Mutations of the TREM2 gene can significantly increase the risk of Alzheimer's disease. Scientists from the German Center for Neurodegenerative Diseases (DZNE) and the Ludwig-Maximilians-University Munich now shed light on the reasons why TREM2 is so important for brain health. They show that ...

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Imaging nerve-cell interactions

04-Jan-2019

A new imaging technique developed by LMU researchers is garnering lots of attention. Based on a method for making tissues, organs and even whole organisms transparent, it promises to transform studies of the nervous system in particular. A new bioimaging technology provides unprecedented insights ...

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The roles of RNA-RNA interactions

Chronic regeneration of damaged endothelial cells promotes the development of atherosclerosis

23-Jul-2018

Atherosclerosis – the condition popularly known as hardening of the arteries – develops almost exclusively at junctions and sharp turns in the arterial tree. This is because, at such sites, the endothelial cells that form the lining of the blood vessels are particularly sensitive to damage – and ...

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