CRISPR-edited C. elegans identifies vulnerabilities in cancer

25-Oct-2019 - At first glance, a one-millimeter worm that needs to be observed with a magnifying glass does not resemble a human being at all. However, the nematode Caenorhabditis elegans, an animal model widely used in biomedical research by hundreds of laboratories around the world, has approximately the ...

An inflammatory diet correlates with colorectal cancer risk

The risk of developing colorectal cancer for individuals that follow a pro-inflammatory diet is two times higher than usual

16-Jul-2019 - Researchers from the Molecular Mechanisms and Experimental Therapy in Oncology program (Oncobell) of the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO), together with the Biodonostia Health Research Institute (IIS Biodonostia), among others, have ...

New antiretroviral drugs decrease chances of HIV sexual transmission

23-Nov-2016 - More than 2 million people got infected by human immunodeficiency virus (HIV) in 2015, being sexual transmission the main channel of infection. Researchers from the Infections of the Respiratory Tract and in Immunocompromised Patients group of the Bellvitge Biomedical Research Institute ...

Therapeutic inhibition of RANK pathway reduces breast cancer recurrence

14-Sep-2016 - Researchers at the Institute of Biomedical Research of Bellvitge (IDIBELL), led by Dr. Eva Gonzalez-Suarez, have shown that pharmacological and genetic inhibition of signaling pathway RANK / RANKL leads to a significant reduction in recurrences and metastases in breast cancer in a mouse animal ...

A new animal model to understand metastasis in sarcomas

31-Aug-2016 - The Sarcoma research group of Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor ...

Camouflaging of viral DNA could be crucial step in progression of cancers

10-Feb-2009 - An estimated 15% of cancer cases can be linked to a viral infection, however the biological changes that cause some asymptomatic carriers of a virus to develop full-blown tumors are not well understood. In a study published in Genome Research, scientists have mapped a chemical modification of ...